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dc.contributor.authorNyberg, Stian Kwak
dc.contributor.authorBerg, Ole Kristian
dc.contributor.authorHelgerud, Jan
dc.contributor.authorWang, Eivind
dc.identifier.citationPhysiological Reports. 2018, 6:e13696 (10), 1-11.nb_NO
dc.description.abstractAssessment of forearm oxygen uptake (O2) during handgrip exercise is a keenly investigated concept for observing small muscle mass metabolism. Although a combination of Doppler ultrasound measurements of brachial artery blood flow () and blood gas drawn from a deep forearm vein has been utilized to calculate forearm O2 for more than two decades, the applicability of this experimental design may benefit from a thorough evaluation of its reliability during graded exercise. Therefore, we evaluated the reliability of this technique during incremental handgrip exercise in ten healthy young (24&nbsp;±&nbsp;3(SD) years.) males. O2 and work rate (WR) exhibited a linear relationship (1.0&nbsp;W: 43.8&nbsp;±&nbsp;10.1&nbsp;mL·min−1; 1.5&nbsp;W: 53.8&nbsp;±&nbsp;14.1&nbsp;mL·min−1; 2.0&nbsp;W: 63.4&nbsp;±&nbsp;16.3&nbsp;mL·min−1; 2.5&nbsp;W: 72.2&nbsp;±&nbsp;17.6&nbsp;mL·min−1; 3.0&nbsp;W: 79.2&nbsp;±&nbsp;18.6&nbsp;mL·min−1; r&nbsp;=&nbsp;0.65, P&nbsp;<&nbsp;0.01). In turn, O2 was strongly associated with (1.0&nbsp;W: 359&nbsp;±&nbsp;86&nbsp;mL·min−1; 1.5&nbsp;W: 431&nbsp;±&nbsp;112&nbsp;mL·min−1; 2.0&nbsp;W: 490&nbsp;±&nbsp;123&nbsp;mL·min−1; 2.5&nbsp;W: 556&nbsp;±&nbsp;112&nbsp;mL·min−1; 3.0&nbsp;W: 622&nbsp;±&nbsp;131&nbsp;mL·min−1; r&nbsp;=&nbsp;0.96; P&nbsp;<&nbsp;0.01), whereas arteriovenous oxygen difference (a‐vO2diff) remained constant following all WRs (123&nbsp;±&nbsp;11–130&nbsp;±&nbsp;10&nbsp;mL·L−1). Average O2 test–retest difference was −0.4&nbsp;mL·min−1 with ±2SD limits of agreement (LOA) of 8.4 and −9.2&nbsp;mL·min−1, respectively, whereas coefficients of variation (CVs) ranged from 4–7%. Accordingly, test–retest difference was 11.9&nbsp;mL·min−1 (LOA: 84.1&nbsp;mL·min−1; −60.4&nbsp;mL·min−1) with CVs between 4 and 7%. Test–retest difference for a‐vO2diff was −0.28&nbsp;mL·dL−1 (LOA: 1.26mL·dL−1; −1.82&nbsp;mL·dL−1) with 3–5% CVs. In conclusion, our results revealed that forearm O2 determination by Doppler ultrasound and direct venous sampling is linearly related to WR, and a reliable experimental design across a range of exercise intensities.nb_NO
dc.publisherWiley Open Accessnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleReliability of forearm oxygen uptake during handgrip exercise : assessment by ultrasonography and venous blood gasnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalPhysiological Reportsnb_NO
dc.description.localcode© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License.nb_NO
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk

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