dc.contributor.author | Hellevik, Alf Inge | |
dc.contributor.author | Nordsletten, Lars | |
dc.contributor.author | Johnsen, Marianne Bakke | |
dc.contributor.author | Fenstad, Anne Marie | |
dc.contributor.author | Furnes, Ove | |
dc.contributor.author | Storheim, Kjersti | |
dc.contributor.author | Zwart, John-Anker | |
dc.contributor.author | Flugsrud, Gunnar B | |
dc.contributor.author | Langhammer, Arnulf | |
dc.date.accessioned | 2018-08-28T13:23:04Z | |
dc.date.available | 2018-08-28T13:23:04Z | |
dc.date.created | 2017-11-02T12:30:20Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Osteoarthritis and Cartilage. 2017, 25 (10), 1654-1662. | nb_NO |
dc.identifier.issn | 1063-4584 | |
dc.identifier.uri | http://hdl.handle.net/11250/2559694 | |
dc.description.abstract | Objective
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis.
Method
In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis. Cox proportional hazards models were used to estimate the hazard ratios (HRs).
Results
We observed 430 TKRs and 675 THRs during a mean follow-up time of 8.3 years. Increasing age at menarche was inversely associated with the risk of TKR (P-trend < 0.001). Past users and users of systemic HRT were at higher risk of TKR compared to never users (HR 1.42 (95% confidence interval (CI) 1.06–1.90) and HR 1.40 (95% CI 1.03–1.90), respectively). No association was found between parity, age at menarche, menopausal status, age at menopause, oral contraceptive use or HRT use and THR.
Conclusion
We found that increasing age at menarche reduced the risk of TKR. Past users and users of systemic HRT were at higher risk of TKR compared to never users. Parity did not increase the risk of THR or TKR. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1654-1662 | nb_NO |
dc.source.volume | 25 | nb_NO |
dc.source.journal | Osteoarthritis and Cartilage | nb_NO |
dc.source.issue | 10 | nb_NO |
dc.identifier.doi | 10.1016/j.joca.2017.06.010 | |
dc.identifier.cristin | 1510271 | |
dc.description.localcode | © 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |