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dc.contributor.authorHellevik, Alf Inge
dc.contributor.authorNordsletten, Lars
dc.contributor.authorJohnsen, Marianne Bakke
dc.contributor.authorFenstad, Anne Marie
dc.contributor.authorFurnes, Ove
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorZwart, John-Anker
dc.contributor.authorFlugsrud, Gunnar B
dc.contributor.authorLanghammer, Arnulf
dc.identifier.citationOsteoarthritis and Cartilage. 2017, 25 (10), 1654-1662.nb_NO
dc.description.abstractObjective To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. Method In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis. Cox proportional hazards models were used to estimate the hazard ratios (HRs). Results We observed 430 TKRs and 675 THRs during a mean follow-up time of 8.3 years. Increasing age at menarche was inversely associated with the risk of TKR (P-trend < 0.001). Past users and users of systemic HRT were at higher risk of TKR compared to never users (HR 1.42 (95% confidence interval (CI) 1.06–1.90) and HR 1.40 (95% CI 1.03–1.90), respectively). No association was found between parity, age at menarche, menopausal status, age at menopause, oral contraceptive use or HRT use and THR. Conclusion We found that increasing age at menarche reduced the risk of TKR. Past users and users of systemic HRT were at higher risk of TKR compared to never users. Parity did not increase the risk of THR or TKR.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleAge of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalOsteoarthritis and Cartilagenb_NO
dc.description.localcode© 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license (
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal