dc.contributor.author | Witter, Menno | |
dc.contributor.author | Ohara, Shinya | |
dc.contributor.author | Onodera, Mariko | |
dc.contributor.author | Simonsen, Øyvind Wilsgård | |
dc.contributor.author | Yoshino, Rintaro | |
dc.contributor.author | Hioki, Hiroyuki | |
dc.contributor.author | Iijima, Toshio | |
dc.contributor.author | Tsutsui, Ken-Ichiro | |
dc.date.accessioned | 2018-07-09T07:25:44Z | |
dc.date.available | 2018-07-09T07:25:44Z | |
dc.date.created | 2018-07-04T17:24:05Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Cell reports. 2018, 24 107-116. | nb_NO |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/11250/2504729 | |
dc.description.abstract | Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal projections, whereas the superficial-sublayer LVa, immunonegative for Ctip2, originates the main outputs of EC. This disrupts the proposed role of EC as mediating hippocampal-cortical interactions. With the use of specific (trans)synaptic tracing approaches, we report that, in medial entorhinal cortex, layer Vb neurons innervate neurons in layers Va, II, and III. A similar circuitry exists in the lateral entorhinal cortex. We conclude that EC-layer Vb neurons mediate two circuits in the hippocampus-memory system: (1) a hippocampal output circuit to telencephalic areas by projecting to layer Va and (2) a feedback projection, sending information back to the EC-hippocampal loop via neurons in layers II and III. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 107-116 | nb_NO |
dc.source.volume | 24 | nb_NO |
dc.source.journal | Cell reports | nb_NO |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2018.06.014 | |
dc.identifier.cristin | 1595717 | |
dc.description.localcode | © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,65,60,0 | |
cristin.unitname | Kavliinstitutt for nevrovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |