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dc.contributor.authorBulanova, Daria
dc.contributor.authorIanevski, Aleksandr
dc.contributor.authorBugai, Andrii
dc.contributor.authorAkimov, Yevhen
dc.contributor.authorKuivanen, Suvi
dc.contributor.authorPaavilainen, Henrik
dc.contributor.authorKakkola, Laura
dc.contributor.authorNandania, Jatin
dc.contributor.authorTurunen, Laura
dc.contributor.authorOhman, Tiina
dc.contributor.authorAla-Hongisto, Hanna
dc.contributor.authorPesonen, Hanna M
dc.contributor.authorKuisma, Marika S
dc.contributor.authorHonkimaa, Anni
dc.contributor.authorWalton, Emma Louise
dc.contributor.authorOksenych, Valentyn
dc.contributor.authorLorey, Martina B.
dc.contributor.authorGuschin, Dmitry
dc.contributor.authorShim, Jungmin
dc.contributor.authorKim, Jinhee
dc.contributor.authorThan, Thoa T
dc.contributor.authorChang, So Young
dc.contributor.authorHukkanen, Veijo
dc.contributor.authorKulesskiy, Evgeny
dc.contributor.authorMarjomaki, Varpu S
dc.contributor.authorJulkunen, Ilkka
dc.contributor.authorNyman, Tuula Anneli
dc.contributor.authorMatikainen, Sampsa
dc.contributor.authorSaarela, Jani S
dc.contributor.authorSane, Famara
dc.contributor.authorHober, Didier
dc.contributor.authorGabriel, Gulsah
dc.contributor.authorDe Brabander, Jef K
dc.contributor.authorMartikainen, Miika
dc.contributor.authorWindisch, Marc P
dc.contributor.authorMin, Ji-Young
dc.contributor.authorBruzzone, Roberto
dc.contributor.authorAittokallio, Tero
dc.contributor.authorVaha-Koskela, Markus
dc.contributor.authorVapalahti, Olli
dc.contributor.authorPulk, Arto
dc.contributor.authorVelagapudi, Vidya
dc.contributor.authorKainov, Denis
dc.date.accessioned2018-06-28T11:02:08Z
dc.date.available2018-06-28T11:02:08Z
dc.date.created2017-11-03T12:24:54Z
dc.date.issued2017
dc.identifier.citationViruses. 2017, 9(10).nb_NO
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11250/2503559
dc.description.abstractViral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPI AGnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAntiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteinsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume9nb_NO
dc.source.journalVirusesnb_NO
dc.source.issue10nb_NO
dc.identifier.doi10.3390/v9100271
dc.identifier.cristin1510729
dc.description.localcode© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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