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dc.contributor.authorTaylor, Amy E
dc.contributor.authorCarslake, David
dc.contributor.authorDe Mola, Christian Loret
dc.contributor.authorRydell, Mina
dc.contributor.authorNilsen, Tom Ivar Lund
dc.contributor.authorBjørngaard, Johan Håkon
dc.contributor.authorHorta, Bernardo Lessa
dc.contributor.authorPearson, Rebecca
dc.contributor.authorRai, Dheeraj
dc.contributor.authorGalanti, Maria Rosaria
dc.contributor.authorBarros, Fernando C.
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorDavey Smith, George
dc.contributor.authorMunafo, Marcus R
dc.identifier.citationScientific Reports. 2017, 7(1).nb_NO
dc.description.abstractPrevious reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health study (HUNT) from Norway (N = 15,493), the Pelotas 1982 Birth Cohort Study from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smoking during pregnancy and mother’s partner’s smoking during pregnancy with offspring depression and performed a discordant sibling analysis. In meta-analysis, maternal smoking during pregnancy was associated with higher odds of offspring depression (OR 1.20, 95% CI:1.08,1.34), but mother’s partner’s smoking during pregnancy was not (OR 1.05, 95% CI:0.94,1.17). However, there was only weak statistical evidence that the odds ratios for maternal and mother’s partner’s smoking differed from each other (p = 0.08). There was no clear evidence for an association between maternal smoking during pregnancy and offspring depression in the sibling analysis. Findings do not provide strong support for a causal role of maternal smoking during pregnancy in offspring depression, rather observed associations may reflect residual confounding relating to characteristics of parents who smoke.nb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMaternal Smoking in Pregnancy and Offspring Depression: A cross cohort and negative control studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalScientific Reportsnb_NO
dc.description.localcode© Te Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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