dc.contributor.author | Strand, Linn B | |
dc.contributor.author | Clarke, Phillip | |
dc.contributor.author | Graves, Nicholas | |
dc.contributor.author | Barnett, Adrian Gerard | |
dc.date.accessioned | 2018-06-22T09:19:55Z | |
dc.date.available | 2018-06-22T09:19:55Z | |
dc.date.created | 2017-09-26T09:13:22Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | BMJ Open. 2017, 7(3). | nb_NO |
dc.identifier.issn | 2044-6055 | |
dc.identifier.uri | http://hdl.handle.net/11250/2502649 | |
dc.description.abstract | Objective: To examine the length of time between receiving funding and publishing the protocol and main paper for randomised controlled trials. Design: An observational study using survival analysis. Setting: Publicly funded health and medical research in Australia. Participants: Randomised controlled trials funded by the National Health and Medical Research Council of Australia between 2008 and 2010. Main outcome measures: Time from funding to the protocol paper and main results paper. Multiple variable survival models examining whether study characteristics predicted publication times. Results: We found 77 studies with a total funding of $A59 million. The median time to publication of the protocol paper was 6.4 years after funding (95% CI 4.1 to 8.1). The proportion with a published protocol paper 8 years after funding was 0.61 (95% CI 0.48 to 0.74). The median time to publication of the main results paper was 7.1 years after funding (95% CI 6.3 to 7.6). The proportion with a published main results paper 8 years after funding was 0.72 (95% CI 0.56 to 0.87). The HRs for how study characteristics might influence timing were generally close to one with narrow CIs, the notable exception was that a longer study length lengthened the time to the main paper (HR=0.62 per extra study year, 95% CI 0.43 to 0.89). Conclusions: Despite the widespread registration of clinical trials, there remain serious concerns of trial results not being published or being published with a long delay. We have found that these same concerns apply to protocol papers, which should be publishable soon after funding. Funding agencies could set a target of publishing the protocol paper within 18 months of funding. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BMJ Publishing Group | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Time to publication for publicly funded clinical trials in Australia: an observational study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 7 | nb_NO |
dc.source.journal | BMJ Open | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.1136/bmjopen-2016-012212 | |
dc.identifier.cristin | 1498053 | |
dc.description.localcode | © Published by the BMJ Publishing Group Limited.This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |