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dc.contributor.authorMidttun, Øivind
dc.contributor.authorTheofylaktopoulou, Despoina
dc.contributor.authorMccann, Adrian
dc.contributor.authorFanidi, Anouar
dc.contributor.authorMuller, David C.
dc.contributor.authorMeyer, Klaus
dc.contributor.authorUlvik, Arve
dc.contributor.authorZheng, Wei
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorPrentice, Ross
dc.contributor.authorThomson, Cynthia A.
dc.contributor.authorPettinger, Mary
dc.contributor.authorGiles, Graham G.
dc.contributor.authorHodge, Allison
dc.contributor.authorCai, Qiuyin
dc.contributor.authorBlot, William J.
dc.contributor.authorWu, Jie
dc.contributor.authorJohansson, Mikael
dc.contributor.authorHultdin, Johan
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorMcCullough, Marjorie L.
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorHveem, Kristian
dc.contributor.authorNæss, Marit
dc.contributor.authorSesso, Howard D.
dc.contributor.authorGaziano, J. Michael
dc.contributor.authorBuring, Julie E.
dc.contributor.authorLee, I-Min
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorZhang, Xuehong
dc.contributor.authorHan, Jiali
dc.contributor.authorStampfer, Meir J.
dc.contributor.authorSmith-Warner, Stephanie A.
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorButler, Lesley M.
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorWang, Renwei
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorEricson, Ulrika
dc.contributor.authorSonestedt, Emily
dc.contributor.authorZiegler, Regina G.
dc.contributor.authorFreedman, Neal D.
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorJones, Miranda R.
dc.contributor.authorRelton, Caroline
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.contributor.authorUeland, Per Magne
dc.identifier.citationAmerican Journal of Clinical Nutrition. 2017, 105 (6), 1314-1326.nb_NO
dc.description.abstractBackground: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5′-phosphate, folate, vitamin B-12, all-trans retinol, 25-hydroxyvitamin D, and α-tocopherol as well as combined vitamin scores that were based on these nutrients showed that the general B-vitamin concentration was highest in the United States and that the B vitamins and lipid soluble vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-vitamin concentration in the United States appears to be driven mainly by multivitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of vitamins and, in particular, the widespread multivitamin-supplement use in the United States. The results provide valuable information about the differences in biomarker concentrations in populations across continents.nb_NO
dc.publisherOxford University Press (OUP)nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCirculating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populationsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalAmerican Journal of Clinical Nutritionnb_NO
dc.description.localcode© 2017 American Society for Nutrition. This is an open access article distributed under the CC-BY license (
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal