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dc.contributor.authorHusebye, Harald
dc.contributor.authorHalaas, Øyvind
dc.contributor.authorStenmark, Harald
dc.contributor.authorTunheim, G
dc.contributor.authorSandanger, Øystein
dc.contributor.authorBogen, B
dc.contributor.authorBrech, A
dc.contributor.authorLatz, Eicke
dc.contributor.authorEspevik, Terje
dc.date.accessioned2018-05-23T07:15:04Z
dc.date.available2018-05-23T07:15:04Z
dc.date.created2006-06-01T12:27:41Z
dc.date.issued2006
dc.identifier.citationEMBO Journal. 2006, 25 683-692.nb_NO
dc.identifier.issn0261-4189
dc.identifier.urihttp://hdl.handle.net/11250/2498792
dc.description.abstractImmune responses are initiated when molecules of microbial origin are sensed by the Toll‐like receptors (TLRs). We now report the identification of essential molecular components for the trafficking of the lipopolysaccharide (LPS) receptor complex. LPS was endocytosed by a receptor‐mediated mechanism dependent on dynamin and clathrin and colocalized with TLR4 on early/sorting endosomes. TLR4 was ubiquitinated and associated with the ubiquitin‐binding endosomal sorting protein hepatocyte growth factor‐regulated tyrosine kinase substrate, Hrs. Inhibition of endocytosis and endosomal sorting increased LPS signaling. Finally, the LPS receptor complex was sorted to late endosomes/lysosomes for degradation and loading of associated antigens onto HLA class II molecules for presentation to CD4+ T cells. Our results show that endosomal trafficking of the LPS receptor complex is essential for signal termination and LPS‐associated antigen presentation, thus controlling both innate and adaptive immunity through TLR4.nb_NO
dc.language.isoengnb_NO
dc.publisherEMBO Pressnb_NO
dc.titleEndocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunitynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber683-692nb_NO
dc.source.volume25nb_NO
dc.source.journalEMBO Journalnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1038/sj.emboj.7600991
dc.identifier.cristin391667
dc.description.localcode© 2006. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: http://emboj.embopress.org/content/25/4/683.longnb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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