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dc.contributor.authorChristoffersen, Tore
dc.contributor.authorAhmed, Luai A.
dc.contributor.authorDaltveit, Anne Kjersti
dc.contributor.authorDennison, Elaine
dc.contributor.authorEvensen, Elin
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorGracia-Marco, Luis
dc.contributor.authorGrimnes, Guri
dc.contributor.authorNilsen, Ole-Andreas
dc.contributor.authorSchei, Berit
dc.contributor.authorTell, Grethe S.
dc.contributor.authorVlachopoulous, Dimitris
dc.contributor.authorWinther, Anne
dc.contributor.authorEmaus, Nina
dc.date.accessioned2018-01-30T15:41:19Z
dc.date.available2018-01-30T15:41:19Z
dc.date.created2017-06-26T12:29:38Z
dc.date.issued2017
dc.identifier.citationArchives of Osteoporosis. 2017, 12 .nb_NO
dc.identifier.issn1862-3514
dc.identifier.urihttp://hdl.handle.net/11250/2480788
dc.description.abstractSummary The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth. Purpose The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents. Methods We included 961 participants from the population-based Fit Futures study (2010–2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC. Results Birth weight was positively associated with BMD-TB and BMC at all sites among girls; standardized β coefficients [95% CI] were 0.11 [0.01, 0.20] for BMD-TB and 0.15 [0.06, 0.24], 0.18 [0.09, 0.28] and 0.29 [0.20, 0.38] for BMC-FN, TH and TB, respectively. In boys, birth weight was positively associated with BMC at all sites with estimates of 0.10 [0.01, 0.19], 0.12 [0.03, 0.21] and 0.15 [0.07, 0.24] for FN, TH and TB, respectively. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment. Conclusions We found a positive association between birth size and BMC in adolescence. However, this association was attenuated after adjustment for weight, height and physical activity during adolescence.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Verlagnb_NO
dc.titleThe influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futuresnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber9nb_NO
dc.source.volume12nb_NO
dc.source.journalArchives of Osteoporosisnb_NO
dc.identifier.doi10.1007/s11657-017-0348-x
dc.identifier.cristin1478843
dc.description.localcodeThis is a post-peer-review, pre-copyedit version of an article published in [Archives of Osteoporosis]. Locked until 18.6.2018 due to copyright restrictions. The final authenticated version is available online at: https://link.springer.com/article/10.1007%2Fs11657-017-0348-xnb_NO
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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