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dc.contributor.authorMaddock, Jane
dc.contributor.authorZhou, Ang
dc.contributor.authorCavadino, Alana
dc.contributor.authorKuźma, Elżbieta
dc.contributor.authorBao, Yanchun
dc.contributor.authorSmart, Melissa C.
dc.contributor.authorSaum, Kai-Uwe
dc.contributor.authorSchöttker, Ben
dc.contributor.authorEngmann, Jorgen
dc.contributor.authorKjærgaard, Marie
dc.contributor.authorKarhunen, Ville
dc.contributor.authorZhan, Yiqiang
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorRovio, Suvi P.
dc.contributor.authorByberg, Liisa
dc.contributor.authorLahti, Jari
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorSen, Abhijit
dc.contributor.authorPerna, Laura
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorSingh-Manoux, Archana
dc.contributor.authorAuvinen, Juha
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorKähönen, Mika
dc.contributor.authorKilander, Lena
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorMelhus, Håkan
dc.contributor.authorIngelsson, Erik
dc.contributor.authorGuessous, Idris
dc.contributor.authorPetrovic, Katja E.
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorVollenweider, Peter
dc.contributor.authorLind, Lars
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorMichaëlsson, Karl
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorHägg, Sara
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorJärvelin, Marjo-Riitta
dc.contributor.authorVeijola, Juha
dc.contributor.authorKivimäki, Mika
dc.contributor.authorJorde, Rolf
dc.contributor.authorBrenner, Hermann
dc.contributor.authorKumari, Meena
dc.contributor.authorPower, Chris
dc.contributor.authorLlewellyn, David J.
dc.contributor.authorHyppönen, Elina
dc.identifier.citationScientific Reports. 2017, 1-8.nb_NO
dc.description.abstractThe causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, pcurvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.nb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleVitamin D and cognitive function: A Mendelian randomisation studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalScientific Reportsnb_NO
dc.description.localcode© The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal