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dc.contributor.authorAstrup, Elisabeth
dc.contributor.authorJanardhanan, J
dc.contributor.authorOtterdal, Kari
dc.contributor.authorUeland, Thor
dc.contributor.authorPrakash, JAJ
dc.contributor.authorLekva, Tove
dc.contributor.authorStrand, Øystein Anders
dc.contributor.authorAbraham, OC
dc.contributor.authorThomas, K
dc.contributor.authorDamås, Jan Kristian
dc.contributor.authorMathews, P
dc.contributor.authorMathai, D
dc.contributor.authorAukrust, Pål
dc.contributor.authorVarghese, GM
dc.identifier.citationPLoS Neglected Tropical Diseases. 2014, 8 (2): e2648.nb_NO
dc.description.abstractBackground: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10–20%, further knowledge of the immune response during scrub typhus is needed. The current study was aimed at comparing plasma levels of a variety of inflammatory mediators in scrub typhus patients and controls in South India in order to map the broader cytokine profile and their relation to disease severity and clinical outcome. Methodology/Principal Findings: We examined plasma levels of several cytokines in scrub typhus patients (n = 129) compared to healthy controls (n = 31) and infectious disease controls (n = 31), both in the acute phase and after recovery, by multiplex technology and enzyme immunoassays. Scrub typhus patients were characterized by marked changes in the cytokine network during the acute phase, differing not only from healthy controls but also from infectious disease controls. While most of the inflammatory markers were raised in scrub typhus, platelet-derived mediators such as RANTES were markedly decreased, probably reflecting enhanced platelet activation. Some of the inflammatory markers, including various chemokines (e.g., interleukin-8, monocyte chemoattractant peptide-1 and macrophage inflammatory protein-1b) and downstream markers of inflammation (e.g., C-reactive protein and pentraxin-3), were also associated with disease severity and mortality during follow-up, with a particular strong association with interleukin-8. Conclusions/Significance: Our findings suggest that scrub typhus is characterized by a certain cytokine profile that includes dysregulated levels of a wide range of mediators, and that this enhanced inflammation could contribute to disease severity and clinical outcome.nb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortalitynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalPLoS Neglected Tropical Diseasesnb_NO
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcodeCopyright 2014 Astrup et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO
cristin.unitnameInstitutt for klinisk og molekylær medisin

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal