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dc.contributor.authorFollin-Arbelet, Virginie
dc.contributor.authorMisund, Kristine
dc.contributor.authorNaderi, Elin Hallan
dc.contributor.authorUgland, Hege Katrin
dc.contributor.authorSundan, Anders
dc.contributor.authorBlomhoff, Heidi Kiil
dc.description.abstractWe have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell lines and primary MM cells by combining the cAMP-elevating compound forskolin with the commonly used MM therapeutic drugs melphalan, cyclophosphamide, doxorubicin, bortezomib and dexamethasone. We observed that forskolin potentiated the killing induced by all the tested agents as compared to treatment with the single agents alone. In particular, forskolin had a synergistic effect on the dexamethasone-responsive cell lines H929 and OM-2. By knocking down the proapoptotic BCL-2 family member BIM, we proved this protein to be involved in the synergistic induction of apoptosis by dexamethasone and forskolin. The ability of forskolin to maintain the killing of MM cells even at lower concentrations of the conventional agents suggests that forskolin may be used to diminish treatment-associated side effects. Our findings support a potential role of forskolin in combination with current conventional agents in the treatment of MM.nb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIMnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalScientific Reportsnb_NO
dc.relation.projectKreftforeningen: 2215992nb_NO
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-007nb_NO
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcode© 2015 The Authors. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.nb_NO
cristin.unitnameInstitutt for klinisk og molekylær medisin

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal