Risk assessment of "other substances" – D-Ribose. Opinion of the Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food and Cosmetics of the Norwegian Scientific Committee for Food Safety
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The Norwegian Scientific Committee for Food Safety (VKM) has, at the request of theNorwegian Food Safety Authority, assessed the risk of intake of 3100 mg pe day and 6200 mg per day of D-ribose in food supplements. In the risk characterization, the values used for comparison with the estimated exposure are 20 g per day (corresponding 286 mg/kg bw per day in a 70 kg adult) from the human studies and a NOAEL of 3.6 g/kg bw per day from the subchronic toxicity and embryotoxicity/teratogenicity studies in rats. VKM concludes that it is unlikely that daily doses of 3100 mg or 6200 mg D-ribose in food supplements causes adverse effects in children (10 to <14 years), adolescents (14 to <18 years) and adults (≥18 years).