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dc.contributor.authorRiise, Hilde Kristin Refvik
dc.contributor.authorSulo, Gerhard
dc.contributor.authorTell, Grethe S.
dc.contributor.authorIgland, Jannicke
dc.contributor.authorNygård, Ottar
dc.contributor.authorVollset, Stein Emil
dc.contributor.authorIversen, Ann-Charlotte
dc.contributor.authorAustgulen, Rigmor
dc.contributor.authorDaltveit, Anne Kjersti
dc.identifier.citationJournal of the American Heart Association. 2017, 6:e004158 (3), 1-13.nb_NO
dc.description.abstractBackground Preeclampsia is a severe pregnancy disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to assess the association between preeclampsia phenotypes and risk of subsequent coronary heart disease and maternal cardiovascular mortality. Methods and Results Women aged 16 to 49 years who gave birth during 1980–2002 and registered in the Medical Birth Registry of Norway were followed prospectively (1–29 years) for an incident major coronary event and mortality through linkage with the Cardiovascular Disease in Norway 1994–2009 (CVDNOR) project and the Norwegian Cause of Death Registry. Preeclampsia was subdivided based on the presence of a child born small for gestational age or preterm delivery. Among 506 350 women with 1 to 5 singleton births, there were 1275 (0.3%) occurrences of major coronary event, 468 (0.1%) cardiovascular deaths, and 5411 (1.1%) deaths overall. Compared with women without preeclampsia, the hazard ratio (95% CI) for major coronary event was 2.1 (1.73–2.65) after preeclampsia alone, 3.3 (2.37–4.57) after preeclampsia in combination with small for gestational age, and 5.4 (3.74–7.74) after preeclampsia in combination with preterm delivery. Analyses distinguishing women with 1 (n=61 352) or >1 (n=281 069) lifetime pregnancy and analyses with cardiovascular mortality as outcome followed the same pattern. Conclusions The occurrence of major coronary events was increased among women with preeclampsia and highest for preeclampsia combined with a child born small for gestational age and/or preterm delivery.nb_NO
dc.publisherWiley Open Accessnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleIncident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and paritynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalJournal of the American Heart Associationnb_NO
dc.relation.projectNorges forskningsråd: 205400nb_NO
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcode(c) 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution License (CC BY-NC)nb_NO
cristin.unitnameCentre of Molecular Inflammation Research (SFF-CEMIR)
cristin.unitnameInstitutt for kreftforskning og molekylær medisin

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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