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dc.contributor.authorSæther, Sverre Georg
dc.contributor.authorSchou, Morten Brix
dc.contributor.authorKondziella, Daniel
dc.description.abstractBackground:Patients with intracellular onconeural antibodies may present with neuro-psychiatric syndromes. Weaimed to evaluate the evidence for an association between well-characterized onconeural antibodies and psychiatricsymptoms in patients with and without paraneoplastic central nervous system syndromes.Methods:Eligible studies were selected from 1980 until February 2017 according to standardized review criteria andevaluated using Quality Assessment of Diagnostic Accuracy Studies−2 (QUADAS-2). We included studies describing thepsychiatric symptomatology of onconeural antibody positive patients and the prevalence of onconeural antibodies inpatients with psychiatric disorders.Results:Twenty-seven studies met the inclusion criteria. Six studies reported on the prevalence of well-characterizedonconeural antibodies in patients with different psychiatric disorders, ranging from 0% to 4.9%. Antibody prevalence incontrols was available from three studies, ranging from 0% to 2.8%. Data heterogeneity precluded a meta-analysis. Twocerebrospinal fluid studies found well-characterized onconeural antibodies in 3.5% and 0% of patients with psychoticand depressive syndromes, respectively.Conclusions:Theavailableevidencesuggeststhattheprevalenceofwell-characterized onconeural antibodies in patientswith psychiatric disorders is generally low. However, the question whether onconeural antibodies are important in selectpatients with a purely psychiatric phenotype needs to be addressed by appropriately designed studies in the future.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleWhat is the significance of onconeural antibodies for psychiatric symptomatology? A systematic reviewnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMC Psychiatrynb_NO
dc.description.localcodeThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.nb_NO
cristin.unitnameInstitutt for helsevitenskap
cristin.unitnameInstitutt for nevromedisin

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