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dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorChristoffersen, terje
dc.contributor.authorAalto, Kristiina
dc.contributor.authorBerntson, Lillemor
dc.contributor.authorFasth, Anders
dc.contributor.authorHerlin, Troels
dc.contributor.authorNielsen, Susan
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorStraume, Bjørn
dc.contributor.authorZak, Marek S.
dc.contributor.authorRygg, Marite
dc.identifier.citationPediatric Rheumatology. 2017, 15 (66), .nb_NO
dc.description.abstractBackground The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. Methods Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for median 98 months in this prospective longitudinal cohort study. Potential clinical and immunological predictors of uveitis were identified with logistic regression analysis. Results Uveitis occurred in 89 (20.5%) of the 435 children with regular ophtalmologic follow-up among the 500 included. Chronic asymptomatic uveitis developed in 80 and acute symptomatic uveitis in 9 children. Uveitis developed at a median interval of 0.8 (range − 4.7 to 9.4) years after onset of arthritis. Predictors of uveitis were age < 7 years at JIA onset (Odds ratio (OR) 2.1, 95% confidence interval (CI) 1.3 to 3.5), presence of antihistone antibodies (AHA) > 15 U/ml (OR 4.8 (1.8 to 13.4)) and antinuclear antibodies (ANA) (OR 2.4 (1.5 to 4.0)). Mean combined IgM/IgG AHA was significantly higher in the uveitis group (19.2 U/ml) than in the non-uveitis group (10.2 U/ml) (p = 0.002). Young age at JIA onset predicted uveitis in girls (p < 0.001), but not in boys (p = 0.390). Conclusion Early-onset arthritis and presence of AHA in girls, as well as presence of ANA in both genders, were significant predictors of chronic uveitis. The high incidence of uveitis in this long-term Nordic JIA cohort may have severe implications in a lifelong perspective.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIncidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study. Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalPediatric Rheumatologynb_NO
dc.identifier.doi. doi: 10.1186/s12969-017-0195-8
dc.description.localcode© The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver( applies to the data made available in this article, unless otherwise stated.nb_NO
cristin.unitnameInstitutt for laboratoriemedisin, barne- og kvinnesykdommer

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Navngivelse 4.0 Internasjonal
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