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dc.contributor.authorLarose, Tricia L
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorChen, Yue
dc.contributor.authorCamargo, Carlos A
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorMai, Xiao-Mei
dc.date.accessioned2017-06-12T10:21:24Z
dc.date.available2017-06-12T10:21:24Z
dc.date.created2014-10-01T15:08:37Z
dc.date.issued2015
dc.identifier.citationEuropean Respiratory Journal. 2015, 45 (4), 1019-1026.nb_NO
dc.identifier.issn0903-1936
dc.identifier.urihttp://hdl.handle.net/11250/2445765
dc.description.abstractThe association between vitamin D status and lung function in adults with asthma remains unclear. We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19–55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L−1 was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals. 44% of asthma adults had serum 25(OH)D levels <50 nmol·L−1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L−1 was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L−1 was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%– −0.25%). Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.nb_NO
dc.language.isoengnb_NO
dc.publisherEuropean Respiratory Societynb_NO
dc.relation.urihttp://erj.ersjournals.com/content/early/2014/11/13/09031936.00069714.full.pdf+html
dc.titleSerum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1019-1026nb_NO
dc.source.volume45nb_NO
dc.source.journalEuropean Respiratory Journalnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1183/09031936.00069714
dc.identifier.cristin1160512
dc.relation.projectNorges forskningsråd: 201895nb_NO
dc.description.localcodeThis is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publicationnb_NO
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for samfunnsmedisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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