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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

dc.contributor.authorRied, Janina S.
dc.contributor.authorJeff, Janina M.
dc.contributor.authorChu, Audrey Y.
dc.contributor.authorBragg-Gresham, Jennifer L.
dc.contributor.authorVan Dongen, Jenny
dc.contributor.authorHuffman, Jennifer E.
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorCadby, Gemma
dc.contributor.authorEklund, Niina
dc.contributor.authorEriksson, Joel
dc.contributor.authorEsko, Tonu
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorGoel, Anuj
dc.contributor.authorGorski, Mathias
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeard-Costa, Nancy L.
dc.contributor.authorJackson, Anne U.
dc.contributor.authorJokinen, Eero
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorKristiansson, Kati
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLahti, Jari
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMägi, Reedik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMangino, Massimo
dc.contributor.authorMedina-Gomez, Carolina
dc.contributor.authorMonda, Keri L.
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorPerusse, Louis
dc.contributor.authorProkopenko, Inga
dc.contributor.authorQi, Lu
dc.contributor.authorRose, Lynda M.
dc.contributor.authorSalvi, Erika
dc.contributor.authorSmith, Megan T.
dc.contributor.authorSnieder, Harold
dc.contributor.authorStandakova, Alena
dc.contributor.authorJu Sung, Yun
dc.contributor.authorTachmazidou, Ioanna
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorVan Der Harst, Pim
dc.contributor.authorWalker, Ryan W.
dc.contributor.authorWang, Sophie R.
dc.contributor.authorWild, Sarah H.
dc.contributor.authorWillems, Stefan M.
dc.contributor.authorWong, Andrew
dc.contributor.authorZhang, Weihua
dc.contributor.authorAlbrecht, Eva
dc.contributor.authorCouto Alves, Alexessander
dc.contributor.authorBakker, Stephan J.L.
dc.contributor.authorBarlassina, Cristina
dc.contributor.authorBartz, Traci M.
dc.contributor.authorBeilby, John
dc.contributor.authorBellis, Claire
dc.contributor.authorBergman, Richard N
dc.contributor.authorBergmann, Sven
dc.contributor.authorBlangero, John
dc.contributor.authorBluher, Matthias
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBonnycastle, Lori L.
dc.contributor.authorBornstein, Stefan R.
dc.contributor.authorBruinenberg, Marcel
dc.contributor.authorCampbell, Harry
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorChiang, Charleston W.K.
dc.contributor.authorChines, Peter S.
dc.contributor.authorCollins, Francis S.
dc.contributor.authorCucca, Fracensco
dc.contributor.authorCupples, L. Adrienne
dc.contributor.authorD'avila, Francesca
dc.contributor.authorde Geus, Eco J.C.
dc.contributor.authorDedoussis, George
dc.contributor.authorDimitriou, Maria
dc.contributor.authorDöring, Angela
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorFarmaki, Aliki-Eleni
dc.contributor.authorFarrall, Martin
dc.contributor.authorFerreira, Teresa
dc.contributor.authorFischer, Krista
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorFriedrich, Nele
dc.contributor.authorGjesing, Anette Prior
dc.contributor.authorGlorioso, Nicola
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorGrallert, Harald
dc.contributor.authorGrarup, Niels
dc.contributor.authorGräßler, Jurgen
dc.contributor.authorGrewal, Jagvir
dc.contributor.authorHamsten, Anders
dc.contributor.authorHarder, Marie Neergaard
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHassinen, Maija
dc.contributor.authorHastie, Nicholas
dc.contributor.authorHattersley, Andrew Tym
dc.contributor.authorHavulinna, Aki S.
dc.contributor.authorHeliövaara, Markku
dc.contributor.authorHillege, Hans
dc.contributor.authorHofman, Albert
dc.contributor.authorHolmen, Oddgeir
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHui, Jennie
dc.contributor.authorHusemoen, Lise Lotte
dc.contributor.authorHysi, Pirro G
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorIttermann, Till
dc.contributor.authorJalilzadeh, Shapour
dc.contributor.authorJames, Alan L
dc.contributor.authorJørgensen, Torben
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorJula, Antti
dc.contributor.authorMarie Justesen, Johanne
dc.contributor.authorJustice, Anne E
dc.contributor.authorKähönen, Mika
dc.contributor.authorKaraleftheri, Maria
dc.contributor.authorTee Khaw, Kay
dc.contributor.authorKeinanen-Kiukaanniemi, Sirkka M
dc.contributor.authorKinnunen, Leena
dc.contributor.authorKnekt, Paul B
dc.contributor.authorKoistinen, Heikki A
dc.contributor.authorKolcic, Ivana
dc.contributor.authorKooner, Ishminder K
dc.contributor.authorKoskinen, Seppo
dc.contributor.authorKovacs, Peter
dc.contributor.authorKyriakou, Theodosios
dc.contributor.authorLaitinen, Tomi
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLewin, Alexandra M
dc.contributor.authorLichtner, Peter
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorLindström, Jaana
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLorbeer, Roberto
dc.contributor.authorLorentzon, Mattias
dc.contributor.authorLuben, Robert
dc.contributor.authorLyssenko, Valeriya
dc.contributor.authorMännistö, Satu
dc.contributor.authorManunta, Paolo
dc.contributor.authorLeach, Irene Mateo
dc.contributor.authorMcardle, Wendy L
dc.contributor.authorMcknight, Barbara
dc.contributor.authorMohlke, Karen L
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMilani, Lili
dc.contributor.authorMills, Rebecca
dc.contributor.authorMontasser, May E
dc.contributor.authorMorris, Andrew P
dc.contributor.authorMuller, Gabriele
dc.contributor.authorMusk, Arthur W
dc.contributor.authorNarisu, Narisu
dc.contributor.authorOng, Ken K
dc.contributor.authorOostra, Ben A
dc.contributor.authorOsmond, Clive
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPankow, James S
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorPenninx, Brenda W
dc.contributor.authorPichler, Irene
dc.contributor.authorPilia, Maria G
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorRao, DC
dc.contributor.authorRayner, Nigel W
dc.contributor.authorRibel-Madsen, Rasmus
dc.contributor.authorRice, Treva K
dc.contributor.authorRichards, Marcus
dc.contributor.authorRidker, Paul M
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRyan, Kathy A
dc.contributor.authorSanna, Serena
dc.contributor.authorSarzynski, Mark A
dc.contributor.authorScholtens, Salome
dc.contributor.authorScott, Robert A
dc.contributor.authorSebert, Sylvain
dc.contributor.authorSoutham, Lorraine
dc.contributor.authorSparsø, Thomas Hempel
dc.contributor.authorSteinthorsdottir, Valgerdur
dc.contributor.authorStirrups, Kathleen
dc.contributor.authorStolk, Ronald P
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorStringham, Heather M
dc.contributor.authorSwertz, Morris A
dc.contributor.authorSwift, Amy J
dc.contributor.authorTönjes, Anke
dc.contributor.authorTsafantakis, Emmanouil
dc.contributor.authorVan Der Most, Peter J
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V
dc.contributor.authorVandenput, Liesbeth
dc.contributor.authorVartiainen, Erkki
dc.contributor.authorVenturini, Cristina
dc.contributor.authorVerweij, Niek
dc.contributor.authorViikari, Jorma S
dc.contributor.authorVitart, Veronique
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorVonk, Judith M
dc.contributor.authorWaeber, Gerard
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWinkler, Thomas W
dc.contributor.authorWright, Alan F
dc.contributor.authorYerges-Armstrong, Laura M
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorCarola Zillikens, M
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorBouchard, Claude
dc.contributor.authorChambers, John C
dc.contributor.authorChasman, Daniel I
dc.contributor.authorCusi, Daniele
dc.contributor.authorGansevoort, Ron T
dc.contributor.authorGieger, Christian
dc.contributor.authorHansen, Torben
dc.contributor.authorHicks, Andrew A
dc.contributor.authorHu, Frank
dc.contributor.authorHveem, Kristian
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKajantie, Eero
dc.contributor.authorKooner, Jaspal S
dc.contributor.authorKuh, Diana
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLaakso, Markku
dc.contributor.authorLakka, Timo A
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorMetspalu, Andres
dc.contributor.authorNjølstad, Inger
dc.contributor.authorOhlsson, Claes
dc.contributor.authorOldehinkel, Albertine J
dc.contributor.authorPalmer, Lyle J
dc.contributor.authorPedersen, Oluf
dc.contributor.authorPerola, Markus
dc.contributor.authorPeters, Annette
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorPuolijoki, Hannu
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorRudan, Igor
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSchwarz, Peter E H
dc.contributor.authorShudiner, Alan R
dc.contributor.authorSmit, Jan H
dc.contributor.authorSørensen, Thorkild I A
dc.contributor.authorSpector, Timothy D
dc.contributor.authorStefansson, Kari
dc.contributor.authorStumvoll, Michael
dc.contributor.authorTremblay, Angelo
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorUusitupa, Matti
dc.contributor.authorVölker, Uwe
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorWatkins, Hugh
dc.contributor.authorWilson, James F
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBorecki, Ingrid B
dc.contributor.authorDeloukas, Panos
dc.contributor.authorVan Duijn, Cornelia M
dc.contributor.authorFox, Caroline
dc.contributor.authorGroop, Leif C
dc.contributor.authorHeid, Iris M
dc.contributor.authorHunter, David J
dc.contributor.authorKaplan, Robert C
dc.contributor.authorMccarthy, Mark I
dc.contributor.authorNorth, Kari E
dc.contributor.authorO'connell, Jeffrey R
dc.contributor.authorSchlessinger, David
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorStrachan, David P
dc.contributor.authorFrayling, Timothy
dc.contributor.authorHirschhorn, Joel N
dc.contributor.authorMuller-Nurasyid, Martina
dc.contributor.authorLoos, Ruth J.F.
dc.date.accessioned2017-03-13T09:12:07Z
dc.date.available2017-03-13T09:12:07Z
dc.date.created2017-01-22T12:37:44Z
dc.date.issued2016
dc.identifier.citationNature Communications. 2016, 7 (13357), 1-11.nb_NO
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11250/2433887
dc.description.abstractLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits,one trait at a time. We examined whether genetic variants affect body shape as a compositephenotype that is represented by a combination of anthropometric traits. We developed anapproach that calculates averaged PCs (AvPCs) representing body shape derived fromsix anthropometric traits (body mass index, height, weight, waist and hip circumference,waist-to-hip ratio). The first four AvPCs explain499% of the variability, are heritable, andassociate with cardiometabolic outcomes. We performed genome-wide association analysesfor each body shape composite phenotype across 65 studies and meta-analysed summarystatistics. We identify six novel loci:LEMD2andCD47for AvPC1,RPS6KA5/C14orf159andGANABfor AvPC3, andARL15andANP32for AvPC4. Our findings highlight the value ofusing multiple traits to define complex phenotypes for discovery, which are not captured bysingle-trait analyses, and may shed light onto new pathways.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.relation.urihttp://www.readcube.com/articles/10.1038/ncomms13357
dc.titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shapenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.pagenumber1-11nb_NO
dc.source.volume7nb_NO
dc.source.journalNature Communicationsnb_NO
dc.source.issue13357nb_NO
dc.identifier.doi10.1038/ncomms13357
dc.identifier.cristin1434863
dc.description.localcodeThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/nb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for samfunnsmedisin
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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