Immobilization does not influence the enantioselectivity of CAL-B catalyzed kinetic resolution of secondary alcohols
Journal article, Peer reviewed
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Original versionTetrahedron: asymmetry. 2005, 16 847-850. http://dx.doi.org/10.1016/j.tetasy.2004.11.081
Decreasing enantioselectivity (E-value) by conversion has been observed in transesterification reactions of secondary alcohols catalyzed by a pure protein formulation of lipase B from Candida antarctica (Novozym 525 F). Addition of a range of enantiopure alcohols caused a temporary increase in enzyme selectivity in the transesterification reaction of 3-chloro-1-phenoxy-2-propanol with vinyl butanoate.