Lipase Catalysed Kinetic Resolution of Stiripentol

Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif; El-Behairy, Mohammed Farrag; Sundby, Eirik; Aboul-Enein, Mohamed Nabil; Attia, Mohamed Ibrahim; El-Azzouny, Aida Abd El-Sattar; Amin, Kamilia M.; Abdel-Rehim, Mohamed
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/2429815
Date
2012
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Original version
International Journal of Chemistry 2012, 4(1):7-13   10.5539/ijc.v4n1p7
Abstract
Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %. Enzymatic hydrolysis of the ester product gave (3R)-Stiripentol with 94 % ee.
Publisher
Canadian Center of Science and Education (CCSE)