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dc.contributor.authorHagen, Knut
dc.contributor.authorOmland, Petter Moe
dc.contributor.authorStovner, Lars Jacob
dc.contributor.authorSand, Trond Halfdan
dc.contributor.authorUglem, Martin
dc.contributor.authorTronvik, Erling Andreas
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorLinde, Anders Mattias
dc.date.accessioned2017-01-13T13:17:45Z
dc.date.available2017-01-13T13:17:45Z
dc.date.created2016-11-20T12:00:32Z
dc.date.issued2016
dc.identifier.citationCephalalgia. 2016.nb_NO
dc.identifier.issn0333-1024
dc.identifier.urihttp://hdl.handle.net/11250/2427259
dc.description.abstractObjective: Studies suggest that pain thresholds may be altered before and during migraine headaches, but it is still debated if a central or peripheral dysfunction is responsible for the onset of pain in migraine. The present blinded longitudinal study explores alterations in thermal pain thresholds and suprathreshold heat pain scores before, during, and after headache. Methods: We measured pain thresholds to cold and heat, and pain scores to 30 seconds of suprathreshold heat four times in 49 migraineurs and once in 31 controls. Sessions in migraineurs were categorized by migraine diaries as interictal, preictal (≤one day before attack), ictal or postictal (≤one day after attack). Results: Trigeminal cold pain thresholds were decreased (p = 0.014) and pain scores increased (p = 0.031) in the ictal compared to the interictal phase. Initial pain scores were decreased (p < 0.029), and the temporal profile showed less adaptation (p < 0.020) in the preictal compared to the interictal phase. Hand cold pain thresholds were decreased in interictal migraineurs compared to controls (p < 0.019). Conclusion:Preictal heat hypoalgesia and reduced adaptation was followed by ictal trigeminal cold suballodynia and heat hyperalgesia. Our results support that cyclic alterations of pain perception occur late in the prodromal phase before headache. Further longitudinal investigation of how pain physiology changes within the migraine cycle is important to gain a more complete understanding of the pathogenic mechanisms behind the migraine attack.nb_NO
dc.language.isoengnb_NO
dc.publisherSAGE Publicationsnb_NO
dc.titleDoes pain sensitivity change by migraine phase? A blinded longitudinal studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalCephalalgianb_NO
dc.identifier.doi10.1177/0333102416679955
dc.identifier.cristin1402099
dc.description.localcode© 2016 by International Headache Society. This is the authors' accepted and refereed manuscript of the article.nb_NO
cristin.unitcode194,65,30,0
cristin.unitnameInstitutt for nevromedisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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