dc.contributor.author | Lønning, Per Eystein | |
dc.contributor.author | Gansmo, Liv Beathe | |
dc.contributor.author | Salvesen, Helga | |
dc.contributor.author | Romundstad, Pål Richard | |
dc.contributor.author | Birkeland, Einar Elvbakken | |
dc.contributor.author | Bjørnslett, Merete Pauline | |
dc.contributor.author | Halle, Mari Kyllesø | |
dc.contributor.author | Dørum, Anne | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Knappskog, Stian | |
dc.contributor.author | Vatten, Lars Johan | |
dc.date.accessioned | 2017-01-13T08:46:13Z | |
dc.date.available | 2017-01-13T08:46:13Z | |
dc.date.created | 2016-04-25T08:39:10Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Tumour Biology. 2016, 37 (8), 10697-10702. | nb_NO |
dc.identifier.issn | 1010-4283 | |
dc.identifier.uri | http://hdl.handle.net/11250/2427195 | |
dc.description.abstract | The MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single nucleotide polymorphism (SNP) in the 3’ untranslated region of the MDM4 gene, SNP34091A > C (rs4245739) was reported to alter MDM4 messenger RNA (mRNA) stability by modulating a microRNA binding site, thereby leading to decreased MDM4 levels. In this case-control study, we aimed to evaluate the possible association between MDM4 SNP34091 status and cancer risk by comparing the genotype frequencies in large hospital-based cohorts of endometrial- (n = 1404) and ovarian (n = 1385) cancer patients with healthy female controls (n = 1870). Genotype frequencies were compared by odds ratio (OR) estimates and Fisher exact tests. We found that individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer (SOC) in general and high-grade serous ovarian cancer (HGSOC) in particular (SOC: OR = 1.18., 95 % CI = 1.01–1.39; HGSOC: OR = 1.25, CI = 1.02–1.53). No association between SNP34091 genotypes and endometrial cancer risk was observed. Our data indicate the MDM4 SNP34091AC/CC genotypes to be associated with an elevated risk for SOC and in particular the HGSOC type. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Verlag | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.source.pagenumber | 10697-10702 | nb_NO |
dc.source.volume | 37 | nb_NO |
dc.source.journal | Tumour Biology | nb_NO |
dc.source.issue | 8 | nb_NO |
dc.identifier.doi | 10.1007/s13277-016-4940-2 | |
dc.identifier.cristin | 1352146 | |
dc.description.localcode | © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |