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dc.contributor.authorLønning, Per Eystein
dc.contributor.authorGansmo, Liv Beathe
dc.contributor.authorSalvesen, Helga
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorBirkeland, Einar Elvbakken
dc.contributor.authorBjørnslett, Merete Pauline
dc.contributor.authorHalle, Mari Kyllesø
dc.contributor.authorDørum, Anne
dc.contributor.authorHveem, Kristian
dc.contributor.authorKnappskog, Stian
dc.contributor.authorVatten, Lars Johan
dc.identifier.citationTumour Biology. 2016, 37 (8), 10697-10702.nb_NO
dc.description.abstractThe MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single nucleotide polymorphism (SNP) in the 3’ untranslated region of the MDM4 gene, SNP34091A > C (rs4245739) was reported to alter MDM4 messenger RNA (mRNA) stability by modulating a microRNA binding site, thereby leading to decreased MDM4 levels. In this case-control study, we aimed to evaluate the possible association between MDM4 SNP34091 status and cancer risk by comparing the genotype frequencies in large hospital-based cohorts of endometrial- (n = 1404) and ovarian (n = 1385) cancer patients with healthy female controls (n = 1870). Genotype frequencies were compared by odds ratio (OR) estimates and Fisher exact tests. We found that individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer (SOC) in general and high-grade serous ovarian cancer (HGSOC) in particular (SOC: OR = 1.18., 95 % CI = 1.01–1.39; HGSOC: OR = 1.25, CI = 1.02–1.53). No association between SNP34091 genotypes and endometrial cancer risk was observed. Our data indicate the MDM4 SNP34091AC/CC genotypes to be associated with an elevated risk for SOC and in particular the HGSOC type.nb_NO
dc.publisherSpringer Verlagnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancernb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalTumour Biologynb_NO
dc.description.localcode© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag

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