Blar i Institutt for bioingeniørfag på utgivelsesdato
Viser treff 1-20 av 75
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The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
(Journal article; Peer reviewed, 2013)Background How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
(Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
(Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2014-11-10)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity
(Journal article; Peer reviewed, 2014-12-23)Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ... -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
(Journal article; Peer reviewed, 2015) -
Gene regulation knowledge commons: community action takes care of DNA binding transcription factors
(Journal article; Peer reviewed, 2016)A large gap remains between the amount of knowledge in scientific literature and the fraction that gets curated into standardized databases, despite many curation initiatives. Yet the availability of comprehensive knowledge ... -
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy
(Journal article; Peer reviewed, 2016)Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well ... -
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells
(Journal article; Peer reviewed, 2016)Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ... -
The Scandinavian small-for-gestational age (SGA) pregnancy and birth cohort – A source to continual insight into fetal growth restriction and long term physical and neurodevelopmental health in mother and offspring
(Peer reviewed; Journal article, 2016)Human in utero growth restriction (IUGR) is associated with an increased risk for perinatal mortality and morbidity among newborns and infants. To pursue this challenge, a Request For Proposals (RFP) was issued in 1983 by ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
(Journal article; Peer reviewed, 2017)Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
(Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Oil type and temperature dependent biodegradation dynamics. Combining chemical and microbial community data through multivariate analysis
(Journal article; Peer reviewed, 2018)Background This study investigates a comparative multivariate approach for studying the biodegradation of chemically dispersed oil. The rationale for this approach lies in the inherent complexity of the data and challenges ... -
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
(Journal article; Peer reviewed, 2018)Chronic inflammation increases the risk of developing one of several types of cancer. Inflammatory responses are currently thought to be controlled by mechanisms that rely on transcriptional networks that are distinct from ... -
Finnes det en sammenheng mellom mikroRNA-21 og tumorsuppresorene PTEN, BTG2 og PDCD4 i prostatavev?
(Bachelor thesis, 2018)miRNA er små deler av DNA som ikke koder for proteiner, men som i stedet festes til mRNA og kan regulere syntesen av proteiner ved å hemme translasjonen. miR-21 har en slik basesekvens at den kan bindes til mRNA for visse ... -
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
(Journal article; Peer reviewed, 2019)Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ... -
A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
(Journal article; Peer reviewed, 2019)While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual ... -
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Når natur møter kultur- en historisk vandrerute gjennom Femundsmarka
(Bachelor thesis, 2019)