Browsing Øvrige samlinger by Journals "Viruses"
Now showing items 1-16 of 16
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A systems approach to study immuno- and neuro-modulatory properties of antiviral agents
(Journal article; Peer reviewed, 2018)There are dozens of approved, investigational and experimental antiviral agents. Many of these agents cause serious side effects, which can only be revealed after drug administration. Identification of the side effects ... -
Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study
(Peer reviewed; Journal article, 2021)Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are ... -
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection
(Peer reviewed; Journal article, 2022)Background: Some viruses cause outbreaks, which require immediate attention. Neutralizing antibodies could be developed for viral outbreak management. However, the development of monoclonal antibodies is often long, ... -
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
(Journal article; Peer reviewed, 2017)Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, ... -
Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression
(Peer reviewed; Journal article, 2023)Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were ... -
Identification and Tracking of Antiviral Drug Combinations
(Peer reviewed; Journal article, 2020)Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ... -
Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword
(Peer reviewed; Journal article, 2022)Coronavirus disease 2019, or COVID-19, is a major challenge facing scientists worldwide. Alongside the lungs, the system of organs comprising the GI tract is commonly targeted by COVID-19. The dysbiotic modulations in the ... -
Influenza virus infection, interferon response, viral counter-response, and apoptosis
(Journal article; Peer reviewed, 2017)Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new ... -
The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence
(Journal article; Peer reviewed, 2023) -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
(Journal article; Peer reviewed, 2019)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host TMPRSS2
(Peer reviewed; Journal article, 2021)SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ... -
Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine
(Peer reviewed; Journal article, 2019)Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral ... -
Novel Synergistic Anti-Enteroviral Drug Combinations
(Peer reviewed; Journal article, 2022)Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ... -
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
(Peer reviewed; Journal article, 2020)As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ... -
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19
(Peer reviewed; Journal article, 2021)Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity ... -
Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections
(Journal article; Peer reviewed, 2021)Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in ...