Non-invasive cortical modulation of experimental pain in migraine
Journal article, Peer reviewed
MetadataVis full innførsel
OriginalversjonClinical Neurophysiology 2016, 127(6):2362-2369 10.1016/j.clinph.2016.03.016
Objective: To test the hypothesis that secondary somatosensory cortex (S2) is involved in the migraine pathogenesis, by exploring the effect of navigated repetitive transcranial magnetic stimulation (rTMS) to S2 on thermal perception and pain. Methods: In this blinded sham-controlled case-control study of 26 interictal migraineurs and 31 controls, we measured thermal detection and pain thresholds on the hand and forehead, and pain ratings to heat stimulation on the forearm and temple, after real and sham 10 Hz rTMS. Results: rTMS increased cold and heat pain thresholds in controls as compared to interictal migraineurs (p < 0.026). rTMS decreased forehead and arm pain ratings (p < 0.005) and increased hand cool detection thresholds (p < 0.005) in both interictal migraineurs and controls. Conclusions: The effects of rTMS to S2 on thermal pain measures differed significantly between migraine and control subjects, although the effects were generally low in magnitude and not present in pain ratings. However, the lack of cold and heat pain threshold increase in migraineurs may reflect a hypofunction of inhibitory pain modulation mechanisms.