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dc.contributor.authorBlatteau, Jean-Eric
dc.contributor.authorBrubakk, Alf O
dc.contributor.authorGempp, Emmanuel
dc.contributor.authorCastagna, Olivier
dc.contributor.authorRisso, Jean-Jacques
dc.contributor.authorVallée, Nicolas
dc.date.accessioned2015-11-24T08:15:06Z
dc.date.accessioned2015-12-09T14:33:23Z
dc.date.available2015-11-24T08:15:06Z
dc.date.available2015-12-09T14:33:23Z
dc.date.issued2013
dc.identifier.citationPLoS ONE 2013, 8(4)nb_NO
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/2367376
dc.description.abstractVascular bubble formation after decompression contributes to endothelial injuries which form the basis for the development of decompression sickness (DCS). Nitric oxide (NO) is a powerful vasodilator that contributes to vessel homeostasis. It has been shown that NO-releasing agent may reduce bubble formation and prevent serious decompression sickness. The use of sildenafil, a well-known, phosphodiesterase-5 blocker, which act by potentiating the vasodilatory effect on smooth muscle relaxation, has never been studied in DCS. The purpose of the present study was to evaluate the clinical effects of sildenafil pre-treatment on DCS in a rat model. 67 rats were subjected to a simulated dive at 90 msw for 45 min before staged decompression. The experimental group received 10 mg/kg of sildenafil one hour before exposure (n = 35) while controls were not treated (n = 32). Clinical assessment took place over a period of 30 min after surfacing. At the end, blood samples were collected for blood cells counts and the level of circulating bubbles in the right cavities was quantified. There were significantly more manifestations of DCS in the sildenafil group than in the controls (34.3% vs 6.25%, respectively, p = 0.012). Platelet count was more reduced in treated rats than in controls (−21.7% vs −7%, respectively, p = 0.029), whereas bubble grades did not differ between groups. We concluded that pre-treatment with sildenafil promotes the onset and severity of neurological DCS. When considering the use of phosphodiesterase-5 blockers in the context of diving, careful discussion with physician should be recommended.nb_NO
dc.language.isoengnb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.titleSidenafil Pre-Treatment Promotes Decompression Sickness in Ratsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-11-24T08:15:06Z
dc.source.volume8nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1371/journal.pone.0060639
dc.identifier.cristin1038061
dc.description.localcode© 2013 Blatteau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO


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