dc.contributor.author | Cao, Hailong | |
dc.contributor.author | Zhou, Qing | |
dc.contributor.author | Lan, Rongfang | |
dc.contributor.author | Røe, Oluf Dimitri | |
dc.contributor.author | Chen, Xin | |
dc.contributor.author | Chen, Yijiang | |
dc.contributor.author | Wang, Dongjin | |
dc.date.accessioned | 2015-11-24T13:06:05Z | |
dc.date.accessioned | 2015-12-04T10:06:32Z | |
dc.date.available | 2015-11-24T13:06:05Z | |
dc.date.available | 2015-12-04T10:06:32Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | PLoS ONE 2014, 9(11) | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2366936 | |
dc.description.abstract | Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped in a case-control study of 840 patients and 845 controls in Chinese population to explore the association between the polymorphism and susceptibility and prognosis of lone AF. As a result, the CT and/or TT genotypes had an increased lone AF risk [adjusted odds ratio (OR) = 1.50 for CT, OR = 3.72 for TT, and OR = 2.15 for CT/TT], compared with the TGF-β1CC genotype. Moreover, patients carrying CT/TT genotypes showed a higher possibility of AF recurrence after catheter ablation, compared with patients carrying CC genotype. In a genotype-phenotype correlation analysis using 24 normal left atrial appendage samples, increasing gradients of atrial TGF-β1 expression levels positively correlated with atrial collagen volume fraction were identified in samples with CC, CT and TT genotypes. The in vitro luciferase assays also showed a higher luciferase activity of the -509T allele than that of the -509C allele. In conclusion, the TGF-β1 C-509T polymorphism is involved in the etiology of lone AF and thus may be a marker for genetic susceptibility to lone AF and predicting prognosis after catheter ablation in Chinese populations. Therefore, we provide new information about treatment strategies and our understanding of TGF-β1 in AF. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.title | A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | en_GB |
dc.date.updated | 2015-11-24T13:06:05Z | |
dc.source.volume | 9 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 11 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0112912 | |
dc.identifier.cristin | 1197635 | |
dc.description.localcode | © 2014 Cao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |