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dc.contributor.authorNestaas, Eirik
dc.contributor.authorStøylen, Asbjørn
dc.contributor.authorFugelseth, Drude
dc.date.accessioned2015-11-10T11:27:53Z
dc.date.accessioned2015-11-23T09:11:29Z
dc.date.available2015-11-10T11:27:53Z
dc.date.available2015-11-23T09:11:29Z
dc.date.issued2012
dc.identifier.citationBMJ Open 2012, 2(4)nb_NO
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11250/2365118
dc.description.abstractObjectives: To investigate one-segment strain and strain rate indices as measures of myocardial performance in asphyxiated term neonates. Design: Quality improvement cohort study. Setting: Newborns admitted to a neonatal intensive care unit at a Norwegian University Hospital for perinatal asphyxia and non-asphyxiated newborn recruited from the maternity ward at the same hospital. Participants: Twenty asphyxiated and 48 non-asphyxiated term neonates. Primary outcome measure: Strain and strain rate indices and repeatability measures. One-segment longitudinal strain and strain rate by tissue Doppler were assessed on days 1, 2 and 3 of life in nine heart walls. Repeatability was compared against measurements from two-segment analyses previously performed in the same images. Results: The 95% limits of agreement were significantly better for the one-segment than two-segment repeatability analyses, the inter-rater peak systolic strain (PSS) was (−3.1, 3.3) vs (−11.4, 18.3)%, the inter-rater peak systolic strain rate (PSSR) was (−0.38, 0.40) vs (−0.79, 1.15)/s, the intra-rater PSS was (−2.5, 2.6) vs (−8.0, 9.8)% and the intra-rater PSSR was (−0.23, 0.25) vs (−0.75, 0.80)/s (p<0.05). The myocardial performance was lower in the asphyxiated neonates (indices closer to zero) than in the non-asphyxiated neonates, PSS was −17.8 (0.6) (mean (SEM)) vs −21.2 (0.3)%, PSSR −1.43 (0.08) vs −1.61 (0.03)/s, early diastolic strain rate 1.72 (0.11) vs 2.00 (0.11)/s and strain rate during the atrial systole 1.92 (0.17) vs 2.27 (0.10)/s (p<0.05), despite no difference in fractional shortening (29.0 (0.5) vs 29.1 (1.0)%) (p>0.05). Conclusions: One-segment strain and strain rate assessed the reduced myocardial performance in asphyxiated neonates with significantly improved reproducibility as compared with two-segment analysis and was therefore more feasible than two-segment analyses for assessment of myocardial performance after perinatal asphyxia.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.titleMyocardial performance assessment in neonates by one-segment strain and strain rate analysis by tissue Doppler - a quality improvement cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-11-10T11:27:53Z
dc.source.volume2nb_NO
dc.source.journalBMJ Opennb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1136/bmjopen-2012-001636
dc.identifier.cristin940939
dc.description.localcodeThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode.nb_NO


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