Blar i Institutt for sirkulasjon og bildediagnostikk på tidsskrift "PLoS ONE"
Viser treff 1-20 av 57
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A multimodal image guiding system for Navigated Ultrasound Bronchoscopy (EBUS): A human feasibility study
(Journal article; Peer reviewed, 2017)Background Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is the endoscopic method of choice for confirming lung cancer metastasis to mediastinal lymph nodes. Precision is crucial for correct staging ... -
A Prospective Population Study of Resting Heart Rate and Peak Oxygen Uptake (the HUNT Study, Norway)
(Journal article; Peer reviewed, 2012)Objectives: We assessed the prospective association of resting heart rate (RHR) at baseline with peak oxygen uptake (VO2peak) 23 years later, and evaluated whether physical activity (PA) could modify this association. ... -
Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats
(Journal article; Peer reviewed, 2017)Introduction: Recent data from long-distance endurance participants suggest that cardiac function is impaired after completion. Existing data further indicate that right ventricular function is more affected than left ... -
Aerobic capacity reference data in 3816 healthy men and women 20-90 years
(Journal article; Peer reviewed, 2013)Purpose: To provide a large reference material on aerobic fitness and exercise physiology data in a healthy population of Norwegian men and women aged 20–90 years. Methods: Maximal and sub maximal levels of VO2, heart ... -
Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure
(Journal article; Peer reviewed, 2013)Background: There is limited knowledge about atrial myocyte Ca2+ handling in the failing hearts. The aim of this study was to examine atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart ... -
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells
(Journal article; Peer reviewed, 2013)Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 ... -
Are Older Adults Physically Active Enough - A Matter of Assessment Method? The Generation 100 Study
(Journal article; Peer reviewed, 2016)Introduction: Physical activity (PA) is beneficial for general health. As a result, adults around the world are recommended to undertake regular PA of either absolute or relative intensity. Traditionally, adherence to PA ... -
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity
(Peer reviewed; Journal article, 2013-10-16)Background: Although high aerobic capacity is associated with effective cardiac function, the effect of aerobic capacity on atrial function, especially in terms of cellular mechanisms, is not known. We aimed to investigate ... -
Autophagy signaling in skeletal muscle of infarcted rats
(Journal article; Peer reviewed, 2014)Background: Heart failure (HF)-induced skeletal muscle atrophy is often associated to exercise intolerance and poor prognosis. Better understanding of the molecular mechanisms underlying HF-induced muscle atrophy may ... -
Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry
(Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Cardiac function in newborns of obese women and the effect of exercise during pregnancy. A randomized controlled trial
(Journal article; Peer reviewed, 2018)Background The prevalence of maternal obesity is rising. Pre-pregnancy obesity is associated with later cardiovascular disease in the child and the underlying pathogenesis begins in early life. Therefore, pregnancy and ... -
Cardio-respiratory reference data in 4631 healthy men and women 20-90 years: The HUNT 3 fitness study
(Journal article; Peer reviewed, 2014)Purpose: To provide a large reference material on key cardio-respiratory variables in a healthy population of Norwegian men and women aged 20–90 years. Methods: Sub maximal and peak levels of cardio-respiratory ... -
Cardiovascular risk factors have larger impact on endothelial function in self-reported healthy women than men in the HUNT3 fitness study
(Journal article; Peer reviewed, 2014)Background: Several studies suggest that cardiovascular risk factors comprising the metabolic syndrome have larger effects on the development of cardiovascular disease in women than in men. A recent study in self-reported ... -
Circulating MicroRNAs and Aerobic Fitness - The HUNT-Study
(Journal article; Peer reviewed, 2013)Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent ... -
Deletion of Kinin B2 receptor alters muscle metabolism and exercise performance
(Journal article, 2015)Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, ... -
Does an integrated care intervention for COPD patients have long-term effects on quality of life and patient activation? A prospective, open, controlled single-center intervention study
(Journal article; Peer reviewed, 2017)Abstract Background Implementation of the COPD-Home integrated disease management (IDM) intervention at discharge after hospitalizations for acute exacerbations of COPD (AECOPD) led to reduced hospital utilization during ... -
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma
(Journal article; Peer reviewed, 2014)There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and ... -
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy
(Journal article; Peer reviewed, 2017)Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after ... -
Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial
(Journal article; Peer reviewed, 2014)Purpose: The training response of an intensified period of high-intensity exercise is not clear. Therefore, we compared the cardiovascular adaptations of completing 24 high-intensity aerobic interval training sessions ... -
Effect of supervised exercise training during pregnancy on neonatal and maternal outcomes among overweight and obese women. Secondary analyses of the ETIP trial: A randomised controlled trial
(Journal article; Peer reviewed, 2017)Background Maternal obesity associates with complications during pregnancy and childbirth. Our aim was to investigate if exercise during pregnancy in overweight/obese women could influence birth weight or other neonatal ...