Browsing Institutt for sirkulasjon og bildediagnostikk by Journals "European Journal of Clinical Pharmacology"
Now showing items 1-4 of 4
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Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil
(Journal article; Peer reviewed, 2018)Purpose Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known ... -
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
(Journal article; Peer reviewed, 2021)Purpose Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. Methods We analysed samples from three pharmacokinetic ... -
Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers
(Journal article; Peer reviewed, 2018)Purpose This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone ... -
Pharmacokinetics of a new, nasal formulation of naloxone
(Journal article; Peer reviewed, 2017)Purpose Nasal naloxone is wanted for bystander administration in opioid overdose and as a needle-free alternative for emergency medical personnel. Epidemiologic studies have indicated a therapeutic effect of bystander ...