• Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 

      Bruno, Raphael Romano; Wernly, Bernhard; Wolff, Georg; Fjølner, Jesper; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C.; Kindgen-Milles, Detlef; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Topeli, Arzu; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Jung, Christian (Peer reviewed; Journal article, 2022)
      Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes ...
    • Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial 

      Langlo, Knut Asbjørn Rise; Lundgren, Kari Margrethe; Zanaboni, Paolo; Mo, Rune; Ellingsen, Øyvind; Hallan, Stein; Aksetøy, Inger-Lise Aamot; Dalen, Håvard (Peer reviewed; Journal article, 2022)
      Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to ...
    • Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score 

      Ofstad, Anne Pernille; Brunborg, Cathrine; Johansen, Odd Erik; Mørkedal, Bjørn; Fagerland, Morten; Laugsand, Lars Erik; Gullestad, Lars; Dalen, Håvard (Peer reviewed; Journal article, 2023)
      Aims Currently, no incident heart failure (HF) risk score that is in regular use in a general population is available. We aimed to develop this and compare with existing HF risk scores. Methods and results Participants ...
    • Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction 

      Bode, David; Rolim, Natale Pinheiro Lage; Guthof, Tim; Hegemann, Niklas; Wakula, Paulina; Primessnig, Uwe; Berre, Anne Marie Ormbostad; Adams, Volker; Wisløff, Ulrik; Pieske, Burkert; Heinzel, Frank R.; Hohendanner, Felix (Peer reviewed; Journal article, 2021)
      Aims Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent disease. Physical exercise has been shown to alter disease progression in HFpEF. We examined cardiomyocyte Ca2+ homeostasis and ...
    • Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

      Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)
      Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...
    • Feasibility of telerehabilitation for heart failure patients inaccessible for outpatient rehabilitation 

      Lundgren, Kari Margrethe; Langlo, Knut Asbjørn Rise; Salvesen, Øyvind; Zanaboni, Paolo; Cittanti, Elisa; Mo, Rune; Ellingsen, Øyvind; Dalen, Håvard; Aksetøy, Inger-Lise Aamot (Peer reviewed; Journal article, 2023)
      Aims Despite strong recommendations, outpatient cardiac rehabilitation is underused in chronic heart failure (CHF) patients. Possible barriers are frailty, accessibility, and rural living, which may be overcome by ...
    • Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure 

      Høydal, Morten; Karevold, Asbjørn; Garstad, Idar Kirkeby; Wiseth, Rune; Haaverstad, Rune; Stølen, Tomas; Contu, Riccardo; Condorelli, Gianluigi; Ellingsen, Øyvind; Smith, Godfrey L; Kemi, Ole J; Wisløff, Ulrik (Journal article; Peer reviewed, 2018)
      Aims Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end‐stage heart failure (HF). To address this limitation, we provide data on ...
    • Impact of different training modalities on high-density lipoprotein function in HFpEF patients: a substudy of the OptimEx trial 

      Sowa, Pamela W.; Winzer, Ephraim B.; Hommel, Jennifer; Männel, Anita; van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Halle, Martin; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2022)
      Aims In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)-bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. ...
    • Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient? 

      Goto, Keita; Schauer, Antje; Augstein, Antje; Methawasin, Mei; Granzier, Henk; Halle, Martin; Craenenbroeck, Emeline M Van; Rolim, Natale Pinheiro Lage; Gielen, Stephan; Pieske, Burkert; Winzer, Ephraim B.; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2021)
      Aims Heart failure with preserved ejection fraction (HFpEF) is associated with reduced exercise capacity elicited by skeletal muscle (SM) alterations. Up to now, no clear medical treatment advice for HFpEF is available. ...
    • Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF 

      Adams, Volker; Wunderlich, Sebastian; Mangner, Norman; Hommel, Jennifer; Esefeld, Katrin; Gielen, Stephan; Halle, Martin; Ellingsen, Øyvind; Van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Linke, Axel; Winzer, Ephraim (Peer reviewed; Journal article, 2021)
      Background Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ...