• Angiogenesis and radiological tumor growth in patients with glioblastoma 

      Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Granli, Unn Sophie; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Journal article; Peer reviewed, 2018)
      Background The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the ...
    • Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model 

      Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)
      Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ...
    • Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer 

      Ottestad, Anine Larsen; Johansen, Håkon; Halvorsen, Tarje Onsøien; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2023)
      Background The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic ...
    • Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized 

      Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ...
    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...
    • Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study 

      Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019)
      Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ...
    • Prognostic value of combined MTV and ADC derived from baseline FDG PET/MRI in aggressive non-Hodgkins lymphoma 

      Husby, Trine; Johansen, Håkon; Bogsrud, Trond; Hustad, Kari Vekseth; Evensen, Birte Veslemøy; Boellaard, Ronald; Giskeødegård, Guro F.; Fagerli, Unn-Merete; Eikenes, Live (Peer reviewed; Journal article, 2022)
      Purpose The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical risk ...
    • Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy 

      Cao, Maria Dung; Giskeødegård, Guro F.; Bathen, Tone Frost; Sitter, Beathe; Bofin, Anna M.; Lønning, Per Eystein; Lundgren, Steinar; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2012)
      Background Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast ...