Blar i Institutt for sirkulasjon og bildediagnostikk på forfatter "Itkonen, Harri"

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    • Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...

    • O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 

      Barkovskaya, Anna; Seip, Kotryna; Hilmarsdòttir, Bylgja; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Itkonen, Harri (Journal article; Peer reviewed, 2019)
      Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the ...

    • Targeted Cancer Therapy: Overcoming Plasticity and Resistance 

      Barkovskaya, Anna (Doctoral theses at NTNU;2019:283, Doctoral thesis, 2019)