Blar i Institutt for samfunnsmedisin og sykepleie på tidsskrift "Cell Genomics"
Viser treff 1-6 av 6
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Genome-wide risk prediction of common diseases across ancestries in one million people
(Peer reviewed; Journal article, 2022)Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast and prostate cancer, we performed ... -
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
(Peer reviewed; Journal article, 2023)Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data ... -
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
(Journal article; Peer reviewed, 2022) -
The HUNT study: A population-based cohort for genetic research
(Peer reviewed; Journal article, 2022)The Trøndelag Health Study (HUNT) is a population-based cohort of ∼229,000 individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway. Approximately 88,000 of these individuals have available genetic ... -
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries
(Peer reviewed; Journal article, 2023)Stroke is the second leading cause of death and disability worldwide. Stroke prevalence varies by sex and ancestry, possibly due to genetic heterogeneity between subgroups. We performed a genome-wide meta-analysis of 16 ... -
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
(Peer reviewed; Journal article, 2022)Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry proteome-wide MR analysis based on ...