Blar i Institutt for samfunnsmedisin og sykepleie på tidsskrift "Scientific Reports"

Viser treff 21-38 av 38

    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...

    • Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation 

      Hegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate; Olsen, Lene Christin; Chawla, Konika; Aas, Per Arne; Sætrom, Pål (Peer reviewed; Journal article, 2021)
      Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-coding RNAs ...

    • Life course trajectories of Maternal Cardiovascular Risk Factors according to Offspring Birthweight: The HUNT Study 

      Horn, Julie; Haug, Eirin Beate; Markovitz, Amanda R; Fraser, Abigail; Vatten, Lars Johan; Romundstad, Pål Richard; Rich-Edwards, Janet W.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Women with small or large for gestational age offspring are at increased risk of cardiovascular disease later in life. How their cardiovascular risk factors develop across the life course is incompletely known. We linked ...

    • Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers 

      Anderson, Emma L.; Williams, Dylan M.; Walker, Venexia M.; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Therapeutic targets for halting the progression of Alzheimer’s disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the Cyclophilin-A matrix metalloproteinase-9 (CypA-MMP9) pathway, ...

    • Maternal Smoking in Pregnancy and Offspring Depression: A cross cohort and negative control study 

      Taylor, Amy E; Carslake, David; De Mola, Christian Loret; Rydell, Mina; Nilsen, Tom Ivar Lund; Bjørngaard, Johan Håkon; Horta, Bernardo Lessa; Pearson, Rebecca; Rai, Dheeraj; Galanti, Maria Rosaria; Barros, Fernando C.; Romundstad, Pål Richard; Davey Smith, George; Munafo, Marcus R (Journal article; Peer reviewed, 2017)
      Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon ...

    • MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer 

      Helwa, Reham; Gansmo, Liv Beathe; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Ryan, Bríd M.; Harris, Curtis C.; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2016)
      Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence cancer risk. ...

    • Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trøndelag Health Study 

      Houge, Ingrid Sæther; Hoff, Mari; Thomas, Ranjeny; Videm, Vibeke (Peer reviewed; Journal article, 2020)
      Persons with rheumatoid arthritis (RA) or diabetes have increased risk of cardiovascular disease (CVD) and higher death rates compared to the general population. This study used data from the population-based Nord-Trøndelag ...

    • Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies 

      Aune, Dagfinn; Sen, Abhijit; Kobeissi, Elsa; Hamer, Mark; Norat, Teresa; Riboli, Eilo (Peer reviewed; Journal article, 2020)
      The association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and ...

    • Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies 

      Aune, Dagfinn; Sen, Abhijit; Kobeissi, Elsa; Hamer, Mark; Norat, Teresa; Riboli, Elio (Journal article; Peer reviewed, 2020)
      The association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and ...

    • Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort 

      Page, Christian Magnus; Nøst, Therese Haugdahl; Djordjilović, Vera; Thoresen, Magne; Frigessi, Arnoldo; Sandanger, Torkjel M; Veierød, Marit Bragelien (Journal article; Peer reviewed, 2022)

    • Primary sclerosing cholangitis and the risk of cancer, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of cohort studies 

      Aune, Dagfinn; Sen, Abhijit; Norat, Teresa; Riboli, Elio; Folseraas, Trine (Journal article; Peer reviewed, 2021)
      Abstract A diagnosis of primary sclerosing cholangitis (PSC) has been associated with increased risk of hepatobiliary cancers, colorectal cancer and all-cause mortality in several studies, while associations with cardiovascular ...

    • Robust bacterial co-occurence community structures are independent of r- and K-selection history. 

      Pettersen, Jakob Peder; Gundersen, Madeleine S.; Almaas, Eivind (Peer reviewed; Journal article, 2021)
      Selection for bacteria which are K-strategists instead of r-strategists has been shown to improve fish health and survival in aquaculture. We considered an experiment where microcosms were inoculated with natural seawater ...

    • The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study 

      Haug, Eirin Beate; Amanda, Markovitz; Abigail, Fraser; Dalen, Håvard; Romundstad, Pål Richard; Åsvold, Bjørn Olav; Rich-Edwards, Janet W.; Horn, Julie (Peer reviewed; Journal article, 2021)
      A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular ...

    • Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks 

      Helland, Ragnhild Holden; Ferles, Alexandros; Pedersen, Andre; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Dunås, Tora; Nibali, Marco Conti; Furtner, Julia; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Tewari, Rishi Nandoe; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre A.; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; Aalders, Tom; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Majewska, Paulina Luiza; Jakola, Asgeir Store; Solheim, Ole Skeidsvoll; Hamer, Philip C. De Witt; Reinertsen, Ingerid; Eijgelaar, Roelant S.; Bouget, David Nicolas Jean-Marie (Peer reviewed; Journal article, 2023)
      Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images ...

    • A study of socio‑economic inequalities in self‑reported oral and general health in South‑East Norway 

      Lyshol, Heidi; Grøtvedt, Liv; Natland Fagerhaug, Tone; Feuerherm, Astrid Jullumstrø; Jakhelln, Gry; Sen, Abhijit (Peer reviewed; Journal article, 2022)
      This study assesses the association between socioeconomic determinants and self-reported health using data from a regional Norwegian health survey. We included 9,068 participants ≥ 25 years. Survey data were linked to ...

    • Systematic assessment of prescribed medications and short-term risk of myocardial infarction - a pharmacopeia-wide association study from Norway and Sweden 

      Sen, Abhijit; Vardaxis, Ioannis; Lindqvist, Bo Henry; Brumpton, Ben Michael; Strand, Linn B; Bakken, Inger Johanne Landsjøåsen; Vatten, Lars Johan; Romundstad, Pål Richard; Ljung, Rickard; Mukamal, Kenneth Jay; Janszky, Imre (Journal article; Peer reviewed, 2019)
      Wholesale, unbiased assessment of Scandinavian electronic health-care databases offer a unique opportunity to reveal potentially important undiscovered drug side effects. We examined the short-term risk of acute myocardial ...

    • Validation of the brief instrument “Health Literacy for School-Aged Children” (HLSAC) among Norwegian adolescents 

      Bjørnsen, Hanne Nissen; Moksnes, Unni Karin; Eilertsen, Mary-Elizabeth B; Espnes, Geir Arild; Haugan, Gørill (Peer reviewed; Journal article, 2022)
      Health literacy (HL) has been identified as an important and modifiable determinant of health. To succeed in promoting HL, it is crucial to evaluate interventions addressing HL using validated instruments. However, HL ...

    • Vitamin D and cognitive function: A Mendelian randomisation study 

      Maddock, Jane; Zhou, Ang; Cavadino, Alana; Kuźma, Elżbieta; Bao, Yanchun; Smart, Melissa C.; Saum, Kai-Uwe; Schöttker, Ben; Engmann, Jorgen; Kjærgaard, Marie; Karhunen, Ville; Zhan, Yiqiang; Lehtimäki, Terho; Rovio, Suvi P.; Byberg, Liisa; Lahti, Jari; Marques-Vidal, Pedro; Sen, Abhijit; Perna, Laura; Schirmer, Henrik; Singh-Manoux, Archana; Auvinen, Juha; Hutri-Kähönen, Nina; Kähönen, Mika; Kilander, Lena; Räikkönen, Katri; Melhus, Håkan; Ingelsson, Erik; Guessous, Idris; Petrovic, Katja E.; Schmidt, Helena; Schmidt, Reinhold; Vollenweider, Peter; Lind, Lars; Eriksson, Johan G.; Michaëlsson, Karl; Raitakari, Olli T; Hägg, Sara; Pedersen, Nancy L.; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Veijola, Juha; Kivimäki, Mika; Jorde, Rolf; Brenner, Hermann; Kumari, Meena; Power, Chris; Llewellyn, David J.; Hyppönen, Elina (Journal article; Peer reviewed, 2017)
      The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D ...