• Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

      Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Peer reviewed; Journal article, 2023)
      Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ...
    • CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia 

      Lim, Bryant; Grøntvedt, Gøril Rolfseng; Bathala, Pradeepthi; Kale, Shraddha S.; Campbell, Christopher T.; Stengelin, Martin; Sando, Sigrid Botne; Prassas, Ioannis; Diamandis, Eleftherios P.; Bråthen, Geir (Peer reviewed; Journal article, 2021)
      Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = ...
    • Longitudinal brain age prediction and cognitive function after stroke 

      Aamodt, Eva Birgitte; Alnæs, Dag; de Lange, Ann-Marie Glasø; Aam, Stina; Schellhorn, Till; Saltvedt, Ingvild Tina; Beyer, Mona Kristiansen; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2022)
      Advanced age is associated with post-stroke cognitive decline. Machine learning based on brain scans can be used to estimate brain age of patients, and the corresponding difference from chronological age, the brain age gap ...
    • Perimenopausal hormone therapy is associated with regional sparing of the CA1 subfield: a HUNT MRI study 

      Pintzka, Carl Wolfgang Schøyen; Håberg, Asta (Journal article; Peer reviewed, 2015)
      Observational studies support a neuroprotective role of hormone therapy (HT) in the perimenopause, with hippocampal size being a widely used biomarker.We investigated the effect of HT started before the onset of menopause ...