Blar i Institutt for nevromedisin og bevegelsesvitenskap på tidsskrift "Nature Communications"
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
(Peer reviewed; Journal article, 2021)Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Peer reviewed; Journal article, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Glia-neuron interactions underlie state transitions to generalized seizures
(Journal article; Peer reviewed, 2019)Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ... -
Large-scale genomics unveil polygenic architecture of human cortical surface area
(Journal article; Peer reviewed, 2015)Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ... -
Novel genetic loci associated with hippocampal volume
(Journal article; Peer reviewed, 2017)The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several ... -
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
(Journal article; Peer reviewed, 2024)Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates ... -
Serum metabolome associated with severity of acute traumatic brain injury
(Peer reviewed; Journal article, 2022)Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, ...