Blar i Institutt for nevromedisin og bevegelsesvitenskap på forfatter "Edwin, Trine Holt"

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    • A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease 

      Edwin, Trine Holt; Henjum, Kristi; Nilsson, Lars N. G.; Watne, Leiv; Persson, Karin Ester Torun; Eldholm, Rannveig Sakshaug; Saltvedt, Ingvild; Halaas, Nathalie Bodd; Selbæk, Geir; Engedal, Knut; Strand, Bjørn Heine; Knapskog, Anne Brita (Peer reviewed; Journal article, 2020)
      Introduction: The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity. We explored if cerebrospinal fluid (CSF) soluble TREM2 ...

    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Solvang, Stein-Erik Hafstad; Watne, Leiv (Peer reviewed; Journal article, 2023)
      INTRODUCTION The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a ...

    • Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease 

      Aksnes, Mari; Edwin, Trine Holt; Saltvedt, Ingvild Tina; Eldholm, Rannveig Sakshaug; Chaudhry, Farrukh Abbas; Halaas, Nathalie Bodd; Myrstad, Marius; Watne, Leiv; Knapskog, Anne Brita (Peer reviewed; Journal article, 2023)
      Introduction Alzheimer’s disease (AD) can be characterised in vivo by biomarkers reflecting amyloid-β (Aβ) and tau pathology. However, there is a need for biomarkers reflecting additional pathological pathways. Matrix ...

    • Trajectories of occupational physical activity and risk of later-life mild cognitive impairment and dementia: the HUNT4 70+ study 

      Zotcheva, Ekaterina; Bratsberg, Bernt Magne; Strand, Bjørn Heine; Jugessur, Astanand; Engdahl, Bo Lars; Bowen, Catherine; Selbæk, Geir; Kohler, Hans-Peter; Harris, Jennifer Ruth; Weiss, Jordan; Tom, Sarah E.; Krokstad, Steinar; Yitayew, Teferi Mekonnen; Edwin, Trine Holt; Stern, Yaakov; Håberg, Asta Kristine; Skirbekk, Vegard Fykse (Peer reviewed; Journal article, 2023)
      Background High levels of occupational physical activity (PA) have been linked to an increased risk of dementia. We assessed the association of trajectories of occupational PA at ages 33–65 with risk of dementia and ...