Blar i Institutt for nevromedisin og bevegelsesvitenskap på tittel
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A general representation of dynamical systems for reservoir computing
(Chapter, 2019)Dynamical systems are capable of performing computation in a reservoir computing paradigm. This paper presents a general representation of these systems as an artificial neural network (ANN). Initially, we implement the ... -
General Risk Factors for Gambling Problems and the Prevalence of Pathological Gambling in Norway
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:126, Doctoral thesis, 2006)Pathological Gambling (PG) has not until recently been scientifically studied. In a series of epidemiological studies prevalences of Pathological gambling were assessed for both men and women, adults and adolescents, and ... -
Generalist, specialist and generic positions experienced by occupational therapists in Norwegian municipalities
(Peer reviewed; Journal article, 2020)Purpose Reforms in the health-care system may impact how health-care professionals perceive and enact their roles. This study aims to examine the way in which occupational therapists experience and describe their roles ... -
Generalized bone loss in early rheumatoid arthritis patients followed for ten years in the biologic treatment era
(Journal article; Peer reviewed, 2014)Background: Osteoporosis is a well-known extra articular manifestation in rheumatoid arthritis (RA). Biologic disease modifying anti rheumatic drugs (DMARDs) has been shown to be superior to synthetic DMARDs to reduce ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
Genetic architecture of subcortical brain structures in 38,851 individuals
(Journal article, 2019)Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus ... -
The genetic architecture of the human cerebral cortex
(Peer reviewed; Journal article, 2020)The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ... -
Genetic control of variability in subcortical and intracranial volumes
(Peer reviewed; Journal article, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Peer reviewed; Journal article, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study
(Peer reviewed; Journal article, 2022)Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ... -
The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change
(Peer reviewed; Journal article, 2021)Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ... -
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ... -
Genetic studies of LRRK2 and PINK1 in Parkinson's disease
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:48, Doctoral thesis, 2007)Background and objectives Parkinson’s disease (PD) is a common neurodegenerative disorder affecting 1% of the elderly. The disease causes a significant burden of illness and cost to society. The causes of PD have remained ... -
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
(Journal article; Peer reviewed, 2015)Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ... -
Genetics and Molecular Pathways in Parkinson's disease and Parkinsonism
(Doctoral theses at NTNU;2018:36, Doctoral thesis, 2018)In this thesis I used a wide range of genetic methodologies and biological strategies to unravel the genetic bases of parkinsonian disorders and their clinical relevance. First, in Paper I, we present the discovery of a ... -
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
(Peer reviewed; Journal article, 2021)Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ... -
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
(Peer reviewed; Journal article, 2022)Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ... -
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
(Peer reviewed; Journal article, 2021)Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor ... -
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
(Peer reviewed; Journal article, 2021)Abstract Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48%–54%), but its genetic architecture ...