Blar i Institutt for nevromedisin og bevegelsesvitenskap på forfatter "Hagen, Knut"

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    • FollowTheSutures: Piloting a new way to administer onabotulinumtoxinA for chronic migraine. 

      Stovner, Lars Jacob; Hagen, Knut; Tronvik, Erling Andreas; Gravdahl, Gøril Bruvik; Burstein, Rami; Dodick, David W. (Peer reviewed; Journal article, 2022)
      Background Anatomical and experimental data indicate that onabotulinimtoxin A could be more efficient and cost-effective for treating chronic migraine with injections targeting the cranial sutures, where collaterals from ...

    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Peer reviewed; Journal article, 2021)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...

    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain 

      Rahman, Shafiqur; Winsvold, Bendik K S; Chavez, Sergio; Børte, Sigrid; Tsepilov, Vakov; Sharapov, Sodbo Zh; Aulchenko, Yurii S.; Hagen, Knut; Fors, Egil Andreas; Hveem, Kristian; Zwart, John Anker Henrik; Meurs, Joyce van; Freidin, Maxim B.; Williams, Frances Mk (Peer reviewed; Journal article, 2021)
      Abstract Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48%–54%), but its genetic architecture ...

    • The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates 

      Stovner, Lars Jacob; Hagen, Knut; Linde, Mattias; Steiner, Timothy J. (Peer reviewed; Journal article, 2022)
      Background According to the Global Burden of Disease (GBD) study, headache disorders are among the most prevalent and disabling conditions worldwide. GBD builds on epidemiological studies (published and unpublished) ...

    • Head-HUNT : the epidemiology of headache in Nord-Trøndelag 

      Hagen, Knut (Doktoravhandlinger ved NTNU, 1503-8181, Doctoral thesis, 2002)
      Headache is a general health problem that couses individual suffering as well as public expense. Research may inncrease the knowledge about headache mechanisms and improve the strategies for headache treatment. This thesis ...

    • Headache and musculoskeletal complaints among subjects with self reported whiplash injury. The HUNT-2 study 

      Myran, Rigmor; Hagen, Knut; Svebak, Sven; Nygaard, Øystein Petter; Zwart, John-Anker (Journal article; Peer reviewed, 2011)
      Background: To evaluate the life-time prevalence of self reported whiplash injury and the relationship to chronic musculoskeletal complaints (MSCs) and headache in a large unselected adult population. Methods: Between ...

    • Headache as a predictor for dementia: The HUNT Study 

      Røttereng, Ane Karoline Stræte; Bosnes, Ole; Stordal, Eystein; Zwart, John-Anker; Linde, Mattias; Stovner, Lars Jacob; Hagen, Knut (Journal article; Peer reviewed, 2015)
      Background: The impact of headache on dementia is largely unknown. This study examined the association between headache and dementia using data from a large population-based study. Methods: This population-based study ...

    • Headache Attributed to Traumatic Injury to the Head: Epidemiological Evidence and Natural Course 

      Nordhaug, Lena Hoem (Doctoral theses at NTNU;2019:58, Doctoral thesis, 2019)

    • Headache following head injury: a population-based longitudinal cohort study (HUNT) 

      Nordhaug, Lena Hoem; Hagen, Knut; Vik, Anne; Stovner, Lars Jacob; Follestad, Turid; Pedersen, Torunn; Gravdahl, Gøril Bruvik; Linde, Mattias (Journal article; Peer reviewed, 2018)
      Background Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether ...

    • Headache service quality: evaluation of quality indicators in 14 specialist-care centres 

      Skramm, S; Uluduz, Derja; Gouveia, Raquel Gil; Jensen, Rigmor Højland; Siva, Aksel; Uygunoglu, Ugur; Gvantsa, Gorgadze; Mania, Maka; Braschinsky, Mark; Filatova, Elena; Latysheva, Nina; Osipova, Vera; Skorobogatykh, Kiril; Azimova, Julia; Straube, Andreas; Eren, Ozan Emre; Martelletti, Paolo; Angelelis, Valerio De; Negro, Andrea; Linde, Mattias; Hagen, Knut; Radojicic, Aleksandra; Zidverc-Trajkovic, Jasna; Podgorac, Ana; Paemeleire, Koen; Annelien, De Pue; Lampl, Christian; Steiner, Timothy J.; Katsarava, Zaza (Journal article; Peer reviewed, 2016)
      Background The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in ...

    • High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019 

      Hagen, Knut; Stovner, Lars Jacob; Zwart, John-Anker (Peer reviewed; Journal article, 2020)
      Background Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investigate ...

    • The impact of topiramate, botulinum toxin type A, and CGRP-antibodies on medication overuse headache in patients with chronic migraine: A protocol for systematic review and meta-analysis 

      Giri, Samita; Tronvik, Erling Andreas; Linde, Mattias; Hagen, Knut (Peer reviewed; Journal article, 2022)
      Medication overuse headache (MOH) is defined as headache occurring ≥15 days/month developing as a consequence of regular overuse of acute or symptomatic headache medication for more than 3 months. MOH is present in more ...

    • Insomnia and risk of chronic musculoskeletal complaints: longitudinal data from the HUNT study, Norway 

      Uhlig, Benjamin Langsæter; Sand, Trond; Nilsen, Tom Ivar Lund; Mork, Paul Jarle; Hagen, Knut (Journal article; Peer reviewed, 2018)
      Background The aim of this study was to investigate the prospective association between insomnia and risk of chronic musculoskeletal complaints (CMSC) and chronic widespread musculoskeletal complaints (CWMSC). A second ...

    • Is chronic low back pain a risk factor for diabetes? The Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)
      Objective The purpose of this study was to examine the risk of diabetes associated with the presence or absence of chronic low back pain, considering both cross-sectional and cohort data. Research design and methods ...

    • Is there a U-shaped relationship between physical activity in leisure time and risk of chronic low back pain? A follow-up in the HUNT Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2016)
      Background Physical activity in leisure time is often considered to have favourable effects on the risk of low back pain (LBP), but demonstrating a definite association in epidemiological studies has proven difficult. The ...

    • Is there an Association between vitamin D status and risk of chronic low bak pain? A nested case-Control analysis in the Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Langhammer, Arnulf; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection. ...

    • Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008 

      Hagen, Knut; Åsberg, Anders Nikolai; Stovner, Lars Jacob; Linde, Mattias; Zwart, John-Anker; Winsvold, Bendik K S; HEUCH, INGRID (Journal article; Peer reviewed, 2018)
      Aims The aim of this population-based historical cohort study was to investigate the influence of lifestyle factors on the risk of developing migraine or tension-type headache (TTH). Methods Data from the Nord-Trøndelag ...

    • Long‐term changes in self‐reported sleep quality and risk of chronic musculoskeletal pain: The HUNT Study 

      Skarpsno, Eivind S.; Nilsen, Tom Ivar Lund; Hagen, Knut; Mork, Paul Jarle (Peer reviewed; Journal article, 2021)
      We examined the association between long‐term (~10 years) changes in self‐reported sleep quality and risk of any chronic musculoskeletal pain and chronic widespread pain. The study comprised data on 6,033 people who ...

    • Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Storheim, Kjersti; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Background There are indications that use of menopausal hormone therapy (MHT) and oral contraceptives (OC) increases the risk of low back pain (LBP), with higher oestrogen levels involved in the underlying mechanisms. ...