Browsing Institutt for nevromedisin og bevegelsesvitenskap by Title
Now showing items 1217-1236 of 3272
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Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
(Peer reviewed; Journal article, 2021)Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ... -
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
(Peer reviewed; Journal article, 2022)Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ... -
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
(Peer reviewed; Journal article, 2021)Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor ... -
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
(Peer reviewed; Journal article, 2021)Abstract Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48%–54%), but its genetic architecture ... -
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
(Journal article; Peer reviewed, 2024)Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ... -
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
(Journal article; Peer reviewed, 2021)Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. ... -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
(Peer reviewed; Journal article, 2022)Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ... -
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
(Journal article; Peer reviewed, 2019)Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ... -
Geriatric assessment with management for older patients with cancer receiving radiotherapy. Protocol of a Norwegian cluster-randomised controlled pilot study
(Journal article; Peer reviewed, 2021)About 50% of patients with cancer are expected to need radiotherapy (RT), and the majority of these are older. To improve outcomes for older patients with cancer, geriatric assessment (GA) with management (GAM) is highly ... -
Geriatric assessment with management for older patients with cancer receiving radiotherapy: a cluster-randomised controlled pilot study
(Journal article; Peer reviewed, 2024)Background: Geriatric assessment and management (GAM) improve outcomes in older patients with cancer treated with surgery or chemotherapy. It is unclear whether GAM may provide better function and quality of life (QoL), ... -
Gir ACE-hemmere og angiotensinreseptorantagonister økt risiko for alvorlig covid-19?
(Peer reviewed; Journal article, 2020)Hypertensjon og diabetes mellitus er risikofaktorer for alvorlig covid-19. Det er blitt reist spørsmål om hvorvidt denne assosiasjonen er relatert til bruk av ACE-hemmere og angiotensin II-reseptorblokkere. -
Gir styrketrening av kne- og hoftemuskulatur med bevegelsesrestriksjoner større bedring av smerte og funksjon enn styrketrening av kne- og hoftemuskulatur uten bevegelsesrestriksjoner for individer med patellofemoralt smertesyndrom?
(Bachelor thesis, 2020)Hensikt: Se om styrketrening av kne- og hoftemuskulatur med bevegelsesrestriksjoner gir større bedring av smerte og funksjon enn styrketrening av kne- og hoftemuskulatur uten bevegelsesrestriksjoner for individer med ... -
Gjenvinning av mobilitet etter hoftebrudd – en prospektiv kohortestudie
(Peer reviewed; Journal article, 2020)Hensikt: Å undersøke hva som karakteriserer eldre med hoftebrudd som ikke gjenvinner mobilitet, samt å beskrive mengden fysioterapi denne gruppen mottar det første året etter hoftebrudd. Design: Prospektiv kohortestudie. ... -
Glia-neuron interactions underlie state transitions to generalized seizures
(Journal article; Peer reviewed, 2019)Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ... -
Glial activation and inflammation along the Alzheimer's disease continuum
(Journal article; Peer reviewed, 2019)Background Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer’s disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, ... -
Glial-Neuronal Interactions in Animal Models of Neurological Disorders that Primarily Affect Children
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:17, Doctoral thesis, 2013) -
Glial-neuronal interactions in experimental brain disorders
(Doktoravhandlinger ved NTNU, 1503-8181; 2005:137, Doctoral thesis, 2005)When [1-13C]glucose and [1,2- 13C]acetate are given simultaneously, information of astrocytic and neuronal metabolism can be obtained in the same animal. This is because acetate is exclusively taken up by astrocytes, while ... -
Glioblastom hos voksne
(Peer reviewed; Journal article, 2023)lioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ... -
Glioblastoma Segmentation: Comparison of Three Different Software Packages
(Journal article; Peer reviewed, 2016)To facilitate a more widespread use of volumetric tumor segmentation in clinical studies, there is an urgent need for reliable, user-friendly segmentation software. The aim of this study was therefore to compare three ... -
Glioblastoma Surgery Imaging-Reporting and Data System: Validation and Performance of the Automated Segmentation Task
(Journal article; Peer reviewed, 2021)For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude ...