Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "eLIFE"

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    • 53BP1 and BRCA1 control pathway choice for stalled replication restart 

      Xu, Yixi; Ning, Shaokai; Wei, Zheng; Xu, Ran; Xu, Xinlin; Xing, Mengtan; Guo, Rong; Xu, Dongyi (Journal article; Peer reviewed, 2017)
      The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated ...

    • The allosteric modulation of complement c5 by knob domain peptides 

      Macpherson, Alex; Laabei, Maisem; Ahdash, Zainab; Graewert, Melissa Ann; Birtley, James R.; Schulze, Monika-Sarah E.D.; Crennell, Susan; Robinson, Sarah A.; Holmes, Ben; Oleinikovas, Vladas; Nilsson, Per H.; Snowden, James; Ellis, Victoria; Mollnes, Tom Eirik; Deane, Charlotte M.; Svergun, Dmitri I.; Lawson, Alastair D.G.; van den Elsen, Jean (Peer reviewed; Journal article, 2021)
      Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 ...

    • An event map of memory space in the hippocampus 

      Deuker, Lorena; Bellmund, Jacob Lukas Sarid; Schröder, Tobias Navarro; Döller, Christian Fritz Andreas (Journal article; Peer reviewed, 2016)
      The hippocampus has long been implicated in both episodic and spatial memory, however these mnemonic functions have been traditionally investigated in separate research strands. Theoretical accounts and rodent data suggest ...

    • Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells 

      Laustsen, Anders; van der Sluis, Renée M.; Gris-Oliver, Albert; Hernández, Sabina Sánchez; Cemalovic, Ena; Tang, Hai Q.; Pedersen, Lars Henning; Uldbjerg, Niels; Jakobsen, Martin R.; Bak, Rasmus O. (Peer reviewed; Journal article, 2021)
      Plasmacytoid dendritic cells (pDCs) constitute a rare type of immune cell with multifaceted functions, but their potential use as a cell-based immunotherapy is challenged by the scarce cell numbers that can be extracted ...

    • Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study 

      Hughes, Amanda M.; Sanderson, Eleanor; Morris, Tim; Ayorech, Ziada; Tesli, Martin Steen; Ask, Helga; Reichborn-Kjennerud, Ted; Andreassen, Ole; Magnus, Per Minor; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Davey Smith, George; Havdahl, Alexandra Karoline Saasen; Howe, Laura D.; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Background: Higher BMI in childhood is associated with emotional and behavioural problems, but these associations may not be causal. Results of previous genetic studies imply causal effects but may reflect influence of ...

    • During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost 

      Almog, Noam; Tocker, Gilad; Bonnevie, Tora; Moser, Edvard Ingjald; Moser, May-Britt; Derdikman, Dori Moshe (Journal article; Peer reviewed, 2019)
      The grid cell network in the medial entorhinal cortex (MEC) has been subject to thorough testing and analysis, and many theories for their formation have been suggested. To test some of these theories, we re-analyzed data ...

    • Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors 

      Talboom, JS; Håberg, Asta; De Both, MD; Naymik, MA; Schrauwen, Isabelle; Lewis, CR; Bertinelli, SF; Hammersland, C; Fritz, MA; Myers, AJ; Hay, M; Barnes, Carol A; Glisky, Elisabeth L; Ryan, L; Huentelman, MJ (Journal article; Peer reviewed, 2019)
      In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer’s disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this ...

    • Functional properties of stellate cells in medial entorhinal cortex layer II 

      Rowland, David Clayton; Obenhaus, Horst-Andreas; Skytøen, Emilie; Zhang, Qiangwei; Kentros, Clifford; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2018)
      Layer II of the medial entorhinal cortex (MEC) contains two principal cell types: pyramidal cells and stellate cells. Accumulating evidence suggests that these two cell types have distinct molecular profiles, physiological ...

    • The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change 

      Fjell, Anders Martin; Grydeland, Håkon; Wang, Yunpeng; Amlien, Inge; Bartrés-Faz, David; Brandmaier, Andreas M.; Düzel, Sandra; Elman, Jeremy; Franz, Carol; Håberg, Asta; Kietzmann, Tim C.; Kievit, Rogier A.; Kremen, William S.; Krogsrud, Stine Kleppe; Kühn, Simone; Lindenberger, Ulman; Macià, Didac; Mowinckel, Athanasia Monika; Nyberg, Lars; Panizzon, Matthew S.; Solé-Padullés, Cristina; Sørensen, Øystein; Westerhausen, Rene; Walhovd, Kristine B (Peer reviewed; Journal article, 2021)
      Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ...

    • Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation 

      Stenberg, Ulf Simon; Li, Jing; Gjuvsland, Arne Bjørke; Persson, Karl; Demitz-Helin, Erik; Gonzalez-Pena, Carles; Yue, Jia-Xing; Gilchrist, Ciaran; Ärengård, Timmy; Ghiaci, Payam; Larsson-Berglund, Lisa; Zackrisson, Martin; Smits, Silvana; Hallin, Johan; Höög, Johanna L.; Molin, Mikael; Liti, Gianni; Omholt, Stig William; Warringer, Jonas (Journal article; Peer reviewed, 2022)

    • Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death 

      Borges, Jazlyn P.; Sætra, Ragnhild Sofie Ragnhildstveit; Volchuk, Allen; Bugge, Marit; Devant, Pascal; Sporsheim, Bjørnar; Kilburn, Bridget R.; Evavold, Charles L.; Kagan, Jonathan C.; Goldenberg, Neil M.; Flo, Trude Helen; Steinberg, Benjamin Ethan (Peer reviewed; Journal article, 2022)
      First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple ...

    • Grid-cell representations in mental simulation 

      Bellmund, Jacob Lukas Sarid; Deuker, Lorena; Schröder, Tobias Navarro; Döller, Christian Fritz Andreas (Journal article; Peer reviewed, 2016)
      Anticipating the future is a key motif of the brain, possibly supported by mental simulation of upcoming events. Rodent single-cell recordings suggest the ability of spatially tuned cells to represent subsequent locations. ...

    • Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila 

      Soldano, Alessia; Alpizar, Yeranddy A; Boonen, Brett; Franco, Luis; Lopez-Requena, Alejandro; Liu, Guangda; Mora, Natalia; Yaksi, Emre; Voets, Thomas; Vennekens, Rudi; Hassan, Bassem A; Talavera, Karel (Journal article; Peer reviewed, 2016)
      Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens ...

    • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight 

      Iurilli, Maria Laura Caminia; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino Antonio Moura; Chirita-Emandi, Adela; Hayes, Alison J; Ikeda, Nayu; Jackson, Rod T.; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Saidi, Olfa; Sebert, Sylvain; Sorić, Maroje; Starc, Gregor; Gregg, Edward W.; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdrakhmanova, Shynar; Ghaffar, Suhaila Abdul; Rahim, Hanan Abdul; Abu-Rmeileh, Niveen M.; Garba, Jamila Abubakar; Acosta-Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmad, Mohamad Hasnan; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Hassan, Soheir; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grethe S.; Torheim, Liv Elin; Wilsgaard, Tom (Peer reviewed; Journal article, 2021)
      From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated ...

    • Histological E-data Registration in rodent Brain Spaces 

      Fuglstad, Jingyi Guo; Saldanha, Pearl; Paglia, Jacopo; Whitlock, Jonathan Robert (Peer reviewed; Journal article, 2023)
      Recording technologies for rodents have seen huge advances in the last decade, allowing users to sample thousands of neurons simultaneously from multiple brain regions. This has prompted the need for digital tool kits to ...

    • Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice 

      Åbjørsbråten, Knut Sindre; Skaaraas, Gry HE Syverstad; Cunen, Celine Marie Løken; Bjørnstad, Daniel Marelius; Binder, Kristin M Gullestad; Bojarskaite, Laura; Jensen, Vidar; Nilsson, Lars; Rao, Shreyas B.; Tang, Wannan; Hermansen, Gudmund Horn; Nagelhus, Erlend Arnulf; Ottersen, Ole Petter; Torp, Reidun; Enger, Rune (Peer reviewed; Journal article, 2022)
      Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ...

    • Interpreting wide-band neural activity using convolutional neural networks 

      Frey, Markus; Doeller, Christian Fritz Andreas; Tanni, Sander; Perrodin, Catherine; O'Leary, Alice; Nau, Matthias; Kelly, Jack; Banino, Andrea; Bendor, Daniel; Lefort, Julie; Caswell, Barry (Peer reviewed; Journal article, 2021)
      Rapid progress in technologies such as calcium imaging and electrophysiology has seen a dramatic increase in the size and extent of neural recordings. Even so, interpretation of this data requires considerable knowledge ...

    • Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia 

      Kennedy, Lauritz Hagen; Glesaaen, Emilie Rylund; Palibrk, Vuk; Pannone, Marco; Wang, Wei; Al-Jabri, Ali; Suganthan, Rajikala; Meyer, Niklas; Austbø, Marie Landa; Lin, Xiaolin; Bergersen, Linda Hildegard; Bjørås, Magnar; Rinholm, Johanne Egge (Peer reviewed; Journal article, 2022)
      Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair ...

    • Landmark-based spatial navigation across the human lifespan 

      Becu, Marcia Constance Noemi; Sheynikhovich, Denis; Ramanoël, Stephen; Tatur, Guillaume; Ozier-Lafontaine, Anthony; Authié, Colas N.; Sahel, José-Alain; Arleo, Angelo (Journal article; Peer reviewed, 2023)

    • Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex 

      Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno (Peer reviewed; Journal article, 2021)
      The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ...