Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "eLIFE"
Viser treff 21-33 av 33
-
Mapping sequence structure in the human lateral entorhinal cortex
(Journal article; Peer reviewed, 2019)Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events ... -
Methotrexate attenuates vascular inflammation through an adenosine- microRNA-dependent pathway
(Peer reviewed; Journal article, 2021)Endothelial cell (EC) activation is an early hallmark in the pathogenesis of chronic vascular diseases. MicroRNA-181b (Mir181b) is an important anti-inflammatory mediator in the vascular endothelium affecting endotoxemia, ... -
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
(Peer reviewed; Journal article, 2020)Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ... -
Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia
(Journal article; Peer reviewed, 2023) -
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
(Peer reviewed; Journal article, 2020)Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord ... -
Postnatal development of retrosplenial projections to the parahippocampal region of the rat
(Journal article; Peer reviewed, 2016)The rat parahippocampal region (PHR) and retrosplenial cortex (RSC) are cortical areas important for spatial cognition. In PHR, head-direction cells are present before eye-opening, earliest detected in postnatal day (P)11 ... -
Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing
(Peer reviewed; Journal article, 2022)The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of research, one centered ... -
Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
(Journal article; Peer reviewed, 2018)We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients ... -
Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
(Peer reviewed; Journal article, 2020)Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 ... -
Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study
(Peer reviewed; Journal article, 2022)Background: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships ... -
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
(Journal article; Peer reviewed, 2019)The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ... -
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes
(Peer reviewed; Journal article, 2022)Maternal genetic effects can be defined as the effect of a mother’s genotype on the phenotype of her offspring, independent of the offspring’s genotype. Maternal genetic effects can act via the intrauterine environment ... -
Weakening of the cognition and height association from 1957 to 2018: Findings from four British birth cohort studies
(Peer reviewed; Journal article, 2023)Background: Taller individuals have been repeatedly found to have higher scores on cognitive assessments. Recent studies have suggested that this association can be explained by genetic factors, yet this does not preclude ...