Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "Frontiers in Aging Neuroscience"
Viser treff 1-19 av 19
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5 Years of Exercise Intervention Did Not Benefit Cognition Compared to the Physical Activity Guidelines in Older Adults, but Higher Cardiorespiratory Fitness Did. A Generation 100 Substudy
(Peer reviewed; Journal article, 2021)Background: Aerobic exercise is proposed to attenuate cognitive decline in aging. We investigated the effect of different aerobic exercise interventions and cardiorespiratory fitness (CRF) upon cognition throughout a 5-year ... -
Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study
(Journal article; Peer reviewed, 2022) -
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
(Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Cerebrospinal fluid A?43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to A?42
(Journal article; Peer reviewed, 2017)Background: Amyloid beta 1–43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer’s disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast ... -
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study
(Journal article; Peer reviewed, 2016)Introduction: Biomarkers that will reliably predict the onset of Alzheimer’s disease (AD) are urgently needed. Although cerebrospinal fluid (CSF) amyloid beta 1–42 (Aβ42), total tau, and phosphorylated tau can be used to ... -
Cerebrospinal fluid levels of amyloid beta 1-43 mirror 1-42 in relation to imaging biomarkers of Alzheimer's disease
(Journal article; Peer reviewed, 2017) -
Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment
(Journal article; Peer reviewed, 2018)In this cross-sectional study, we sought to describe cognitive and neuroimaging profiles of Memory clinic patients with Mild Cognitive Impairment (MCI). 51 MCI patients and 51 controls, matched on age, sex, and socio-economic ... -
Cortical thickness changes after computerized working memory training in patients with mild cognitive impairment
(Peer reviewed; Journal article, 2022)Background: Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related ... -
Effects of a 5-Year Exercise Intervention on White Matter Microstructural Organization in Older Adults. A Generation 100 Substudy
(Peer reviewed; Journal article, 2022)Aerobic fitness and exercise could preserve white matter (WM) integrity in older adults. This study investigated the effect on WM microstructural organization of 5 years of exercise intervention with either supervised ... -
Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers
(Journal article; Peer reviewed, 2014)Mutations in the leucine-rich repeat kinase 2 gene are the most common cause of autosomal dominant Parkinson’s disease (PD). To assess the cerebrospinal fluid (CSF) levels of α-synuclein oligomers in symptomatic and ... -
Exergaming in older adults: the effects of game characteristics on brain activity and physical activity
(Peer reviewed; Journal article, 2023)Introduction: Exergames are increasingly used in rehabilitation settings for older adults to train physical and cognitive abilities. To meet the potential that exergames hold, they need to be adapted to the individual ... -
Experiences of Stroke Survivors and Clinicians With a Fully Immersive Virtual Reality Treadmill Exergame for Stroke Rehabilitation: A Qualitative Pilot Study
(Peer reviewed; Journal article, 2021)Use of VR-games is considered a promising treatment approach in stroke rehabilitation. However, there is little knowledge on the use and expectations of patients and health professionals regarding the use of treadmill ... -
Leisure-Time Physical Activity Is Associated With Reduced Risk of Dementia-Related Mortality in Adults With and Without Psychological Distress: The Cohort of Norway
(Journal article; Peer reviewed, 2018)Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations ... -
MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression
(Journal article; Peer reviewed, 2017)Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to ... -
Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study
(Peer reviewed; Journal article, 2023)Background: The severity, progression, and outcomes of motor and non-motor symptoms in Parkinson’s disease (PD) are quite variable. Following PD cohorts holds promise for identifying predictors of disease severity and ... -
Neuroimaging markers of dual impairment in cognition and physical performance following stroke: The Nor-COAST study
(Peer reviewed; Journal article, 2022)Background: Cognitive decline and decline in physical performance are common after stroke. Concurrent impairments in the two domains are reported to give increased risk of dementia and functional decline. The concept of ... -
Older and Wiser: Interpretation of Proverbs in the Face of Age-Related Cortical Atrophy
(Journal article; Peer reviewed, 2022) -
Predicting the Emergence of Major Neurocognitive Disorder Within Three Months After a Stroke
(Peer reviewed; Journal article, 2021)Background: Neurocognitive disorder (NCD) is common after stroke, with major NCD appearing in about 10% of survivors of a first-ever stroke. We aimed to classify clinical- and imaging factors related to rapid development ... -
Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects
(Peer reviewed; Journal article, 2021)Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-ε) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) ...