Blar i Fakultet for medisin og helsevitenskap (MH) på tittel

Viser treff 8369-8388 av 14995

    • Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms 

      Nymark, Marianne; Finazzi, Giovanni; Volpe, Charlotte; Serif, Manuel Philipp; Fonseca, Davi de Miranda; Sharma, Animesh; Sanchez Puerto, Nicolas; Sharma, Amit Kumar; Ashcroft, Felicity Jayne; Kissen, Ralph; Winge, Per; Bones, Atle Magnar (Peer reviewed; Journal article, 2023)
      The chloroplast signal recognition particle (CpSRP) receptor (CpFTSY) is a component of the CpSRP pathway that post-translationally targets light-harvesting complex proteins (LHCPs) to the thylakoid membranes in plants and ...

    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...

    • Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation 

      Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro; Kunath, Nicolas; Johansen, Jostein; Erlandsen, Sten Even; Liabakk, Nina-Beate; Rian, Kristin; Bjørås, Magnar; Sætrom, Pål; van Loon, Barbara (Peer reviewed; Journal article, 2020)
      Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, ...

    • Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia 

      Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug; Hovland, Anders; Berge, Christ; van Lennep, Jeanine Roeters; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2021)
      Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when ...

    • Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice 

      Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Journal article; Peer reviewed, 2017)
      The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ...

    • Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease 

      Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars; Gagliano Taliun, Sarah; Sidore, Carlo; Liu, Yuhao; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke; Overton, William; Zhao, Ying; Chen, Jin; Zhang, He; Hornsby, Whitney E.; Acheampong, Akua; Grooms, Austen; Schaefer, Amanda; Zajac, Gregory J.M.; Villacorta, Luis; Zhang, Jifeng; Brumpton, Ben Michael; Løset, Mari; Rai, Vivek; Lundegaard, Pia R.; Olesen, Morten S.; Taylor, Kent D.; Palmer, Nicholette D.; Chen, Yii-Der; Choi, Seung Hoan; Lubitz, Steven A.; Ellinor, Patrick T.; Barnes, Kathleen C.; Daya, Michelle; Rafaels, Nicholas; Weiss, Scott T.; Lasky-Su, Jessica; Tracy, Russell P.; Vasan, Ramachandran S.; Cupples, L. Adrienne; Mathias, Rasika A.; Yanek, Lisa R.; Becker, Lewis; Holmen, Oddgeir Lingaas; Åsvold, Bjørn Olav; Willer, Christen; Hveem, Kristian (Peer reviewed; Journal article, 2020)
      Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse ...

    • A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment 

      Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ...

    • Lost in the loop - A qualitative study on patient experiences of care in standardized cancer patient pathways 

      Solberg, Monica; Berg, Geir Vegar; Andreassen, Hege Kristin (Peer reviewed; Journal article, 2023)
      Background: The Norwegian health authorities introduced standardized cancer patient pathways (CPPs) in 2015, aiming to reduce practice variations across hospitals and regions, and improve the continuity, coordination and ...

    • Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC 

      Lie, Marie; Pedersen, Linda Margareth; Heuch, Ingrid; Winsvold, Bendik K S; Gjerstad, Johannes; Hasvik, Eivind Olay; Nygaard, Øystein Petter; Grotle, Margreth; Matre, Dagfinn; Zwart, John Anker Henrik; Nilsen, Kristian Bernhard (Peer reviewed; Journal article, 2022)
      In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is ...

    • Low back pain: Prognostic and associated factors within a biopsychosocial framework 

      Nordstoga, Anne Lovise (Doctoral theses at NTNU;2020:100, Doctoral thesis, 2020)
      Korsryggsmerter: Prognostiske og assosierte faktorer innenfor et biopsykososialt rammeverk Korsryggsmerter er en av de ledende årsakene til nedsatt funksjon og arbeidsevne både i Norge og globalt, og fører til utstrakt ...

    • Low bone mineral density is a significant risk factor for low-energy distal radius fractures in middle-aged and elderly men: A case-control study 

      Øyen, Jannike; Rohde, Gudrun Elin; Hochberg, Marc C.; Johnsen, Villy; Haugeberg, Glenn (Journal article; Peer reviewed, 2011)
      Background: In general there is a lack of data on osteoporosis and fracture in men; this also includes low-energy distal radius fractures. The objectives of this study were to examine BMD and identify factors associated ...

    • Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

      Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)
      Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...

    • Low cholesterol level as a risk marker of inpatient and post-discharge violence in acute psychiatry : a prospective study with a focus on gender differences 

      Eriksen, Bjørn Magne Sundsbø; Bjørkly, Stål; Lockertsen, Øyvind; Færden, Ann; Roaldset, John Olav (Journal article; Peer reviewed, 2017)
      Several studies indicate an association between low levels of serum cholesterol and aggressive behaviour, but prospective studies are scarce. In this naturalistic prospective inpatient and post-discharge study from an acute ...

    • Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer 

      Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Leirvaag, Beryl; Miletic, Hrvoje; Lønning, Per Eystein (Journal article; Peer reviewed, 2012)
      Introduction Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 ...

    • Low fat, low lactose diet used as prophylactic treatment of acute intestinal reactions during pelvic radiotherapy. A prospective randomised study 

      Bye, Asta (Dissertations at the Faculty of Medicine, 0805-7680; 203, Doctoral thesis, 2002)
      Purpose. The main aim of the present study was to evaluate the effect of a low fat, low lactose diet on acute and late gastrointestinal side effects of pelvic radiotherapy. We also wanted to evaluate if such a treatment ...

    • Low free testosterone and prostate cancer risk: A collaborative analysis of 20 prospective studies 

      Watts, Eleanor L.; Appleby, Paul N.; Perez-Cornago, Aurora; Bueno-De-Mesquita, Hendrik Bastiaan; Chan, June M.; Chen, Chu; Cohn, Barbara A.; Cook, Michael B.; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward; Gislefoss, Randi Elin; Hankey, Graeme J.; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N.; Kubo, Tatsuhiko; Le Marchand, Loïc; Luben, Robert N.; Luostarinen, Tapio; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Milne, Roger L.; Ozasa, Kotaro; Platz, Elizabeth A.; Quirós, José Ramón; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank Z.; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherine M.; Thompson, Ian M.; Tsilidis, Konstantinos K.; Tsugane, Shoichiro; Ursin, Giske; Vatten, Lars Johan; Weiss, Noel S.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Peer reviewed, 2018)
      Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in ...

    • Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler 

      Ødegård, Siv Steinsmo; Torp, Hans; Follestad, Turid; Leth-Olsen, Martin; Støen, Ragnhild; Nyrnes, Siri Ann (Peer reviewed; Journal article, 2022)
      Background: A cerebroprotective effect of low frequency oscillations (LFO) in cerebral blood flow (CBF) has been suggested in adults, but its significance in neonates is not known. This observational study evaluates normal ...

    • Low grade albuminuria as a risk factor for subtypes of stroke - the HUNT Study in Norway 

      Horn, Jens; Romundstad, Solfrid; Ellekjær, Hanne; Janszky, Imre; Horn, Julie (Peer reviewed; Journal article, 2020)
      Background and purpose Albuminuria is a marker for endothelial dysfunction and knowledge on its association with stroke and stroke subtypes are limited. Methods Corresponding data from 7261 participants of the ...

    • Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life 

      Jakola, Asgeir S; Unsgård, Geirmund; Myrmel, Kristin Smistad; Kloster, Roar; Torp, Sverre Helge; Lindal, Sigurd; Solheim, Ole (Journal article; Peer reviewed, 2012)
      Background: Surgical management of suspected LGG remains controversial. A key factor when deciding a surgical strategy is often the tumors’ perceived relationship to eloquent brain regions Objective: To study the association ...

    • Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients 

      Mjøen, Geir; Hartmann, Anders; Åsberg, Anders; Rollag, Halvor; Mollnes, Tom Eirik; Sandvik, Leiv; Fagerland, Morten; Thiel, Steffen; Sagedal, Solbjørg; Smedbråten, Julia (Journal article; Peer reviewed, 2016)
      Background Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement ...