Browsing Fakultet for medisin og helsevitenskap (MH) by Title
Now showing items 2639-2658 of 14995
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Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model
(Journal article; Peer reviewed, 2011)Background Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target ... -
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
(Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Cycling at Altitude: Lower Absolute Power Output as the Main Cause of Lower Gross Efficiency
(Peer reviewed; Journal article, 2019)Background: Although cyclists often compete at altitude, the effect of altitude on gross efficiency (GE) remains inconclusive. Purpose: To investigate the effect of altitude on GE at the same relative exercise intensity ... -
A cycling exergaming platform to improve cardiorespiratory fitness and encourage independent exercise behaviour among adults
(Doctoral theses at NTNU;2021:304, Doctoral thesis, 2021) -
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
(Journal article, 2016)Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
(Journal article, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
(Journal article; Peer reviewed, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
The Cyclooxygenase 2 inhibitor etoricoxib as adjunctive therapy in tuberculosis impairs macrophage control of mycobacterial growth
(Peer reviewed; Journal article, 2023)Background Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with ... -
CYP2C19 – genvariant CYP2C19*17 og rask omsetting av legemidler
(Master thesis, 2011)Mutasjoner i genene som koder for CYP-enzymene med klinisk betydning, påvirker aktiviteten til enzymet. Doseringen av legemidler må tilpasses for å oppnå den ønskede responsen på legemiddelbehandlingen. Genet CYP2C19 koder ... -
Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans
(Doctoral theses at NTNU;2017:244, Doctoral thesis, 2017)Cytokrom P-450 (CYP) inhibering av kommersielle Rhodiola rosea produkter in vitro og i mennesker. Rosenrot (Rhodiola rosea) er et populært naturprodukt med en global utbredelse. Tidligere studier har vist at naturprodukter ... -
Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality
(Journal article; Peer reviewed, 2014)Background: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10–20%, further knowledge of the immune response during ... -
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
(Peer reviewed; Journal article, 2023)Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ... -
Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond
(Peer reviewed; Journal article, 2021)Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ... -
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients
(Journal article; Peer reviewed, 2018)Background There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted ... -
Cytokine profiles in human metapneumovirus infected children: Identification of genes involved in the antiviral response and pathogenesis
(Journal article; Peer reviewed, 2016)Human metapneumovirus (hMPV) causes severe airway infection in children that may be caused by an unfavorable immune response. The nature of the innate immune response to hMPV in naturally occurring infections in children ... -
Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
(Journal article; Peer reviewed, 2018) -
Cytokine profiling as a measure of immunological development and deviation throughout pregnancy in healthy women and women with PCOS
(Doctoral theses at NTNU;2022:183, Doctoral thesis, 2022)Norsk sammendrag Cytokinprofilering som mål på immunologiske forandringer gjennom svangerskapet hos friske kvinner og kvinner med PCOS Mors immunsystem tilpasser seg gjennom de ulike fasene av svangerskapet for å sikre ... -
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
(Journal article; Peer reviewed, 2017)Background The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the ... -
Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
(Journal article; Peer reviewed, 2019)Background:Different psychiatric diagnostic groups have been reported to have cytokine levels deviating from healthy controls. In acute clinical settings however, the specific challenging symptoms and signs are more important ... -
Cytokines in Relation to Motor Activity in an Acute Psychiatric Population
(Peer reviewed; Journal article, 2019)Background: Deviations in motor activity are important clinical features of several psychiatric disorders in an acute state. Immune activity is associated with several psychiatric disorders and may affect motor activity. ...