Blar i Fakultet for medisin og helsevitenskap (MH) på tidsskrift "Frontiers in Oncology"
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Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study
(Peer reviewed; Journal article, 2023)Background: The serum metabolome is a potential source of molecular biomarkers associated with the risk of breast cancer. Here we aimed to analyze metabolites present in pre-diagnostic serum samples collected from healthy ... -
Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study
(Peer reviewed; Journal article, 2023)Objective: To investigate differences in cardiovascular disease (CVD) morbidity and mortality after radical prostatectomy or definitive radiotherapy with or without androgen deprivation therapy (ADT). Materials and ... -
The central role of gastrin in gastric cancer
(Peer reviewed; Journal article, 2023)The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ... -
Demonstration of non-gaussian restricted diffusion in tumor cells using diffusion time-dependent diffusion-weighted magnetic resonance imaging contrast
(Peer reviewed; Journal article, 2016)The diffusion-weighted magnetic resonance imaging (DWI) technique enables quantification of water mobility for probing microstructural properties of biological tissue and has become an effective tool for collecting information ... -
Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI
(Peer reviewed; Journal article, 2020)Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ... -
Elevated Serum Lactate in Glioma Patients: Associated Factors
(Peer reviewed; Journal article, 2022)Introduction: Serum lactate levels in brain cancer patients correlate with tumor malignancy grading, and serum lactate has been suggested as a potential biomarker and prognostic factor. The purpose of this study was to ... -
The Essential Role of Open Data and Software for the Future of Ultrasound-Based Neuronavigation
(Peer reviewed; Journal article, 2020)With the recent developments in machine learning and modern graphics processing units (GPUs), there is a marked shift in the way intra-operative ultrasound (iUS) images can be processed and presented during surgery. Real-time ... -
Hidden treasures in "ancient" microarrays: Gene expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue
(Journal article; Peer reviewed, 2014)Objective: Novel statistical methods and increasingly more accurate gene annotations can transform “old” biological data into a renewed source of knowledge with potential clinical relevance. Here, we provide an in silico ... -
Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies.
(Journal article; Peer reviewed, 2016-01-28)Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ... -
Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies.
(Journal article; Peer reviewed, 2016)Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ... -
Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment
(Peer reviewed; Journal article, 2022)The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein ... -
Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions
(Peer reviewed; Journal article, 2021)Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy ... -
Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies
(Peer reviewed; Journal article, 2021)Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ... -
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
(Peer reviewed; Journal article, 2022)Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ... -
A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
(Peer reviewed; Journal article, 2022)Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy ... -
Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model
(Journal article; Peer reviewed, 2017)Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced ... -
Pelvic PET/MR attenuation correction in the image space using deep learning
(Peer reviewed; Journal article, 2023) -
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes
(Peer reviewed; Journal article, 2023)IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less ... -
Prolonged Sitting, Its Combination With Physical Inactivity and Incidence of Lung Cancer: Prospective Data From the HUNT Study
(Journal article; Peer reviewed, 2019)Background: Prolonged sitting as a major sedentary behavior potentially contributes to illness, but its relation with lung cancer risk is unclear. Prolonged sitting can be presented in physically active or inactive ... -
Reduced LDL-Cholesterol and Reduced Total Cholesterol as Potential Indicators of Early Cancer in Male Treatment-Naïve Cancer Patients With Pre-cachexia and Cachexia
(Peer reviewed; Journal article, 2020)Cancer cachexia is characterized by the impairment of glucose and lipid homeostasis, the acceleration of processes promoting the mobilization of energy-rich compounds (e.g., insulin resistance, gluconeogenesis, and lipolysis) ...