Browsing Fakultet for medisin og helsevitenskap (MH) by Journals "Cell reports"
Now showing items 1-20 of 27
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Allocentric representation in the human amygdala and ventral visual stream
(Peer reviewed; Journal article, 2021)The hippocampus and the entorhinal cortex are considered the main brain structures for allocentric representation of the external environment. Here, we show that the amygdala and the ventral visual stream are involved in ... -
Architectural organization of ∼1,500-neuron modular minicolumnar disinhibitory circuits in healthy and Alzheimer's cortices
(Peer reviewed; Journal article, 2023)Acquisition of neuronal circuit architectures, central to understanding brain function and dysfunction, remains prohibitively challenging. Here I report the development of a simultaneous and sequential octuple-sexdecuple ... -
A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
(Peer reviewed; Journal article, 2020)Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the ... -
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation
(Journal article; Peer reviewed, 2019)Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte ... -
Convergent projections from perirhinal and postrhinal cortices suggest a multisensory nature of lateral but not medial entorhinal cortex
(Journal article; Peer reviewed, 2019)The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial ... -
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
(Peer reviewed; Journal article, 2021)Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ... -
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility
(Peer reviewed; Journal article, 2023)Eukaryotic RNA pol II transcripts are capped at the 5′ end by the methylated guanosine (m7G) moiety. In higher eukaryotes, CMTR1 and CMTR2 catalyze cap-proximal ribose methylations on the first (cap1) and second (cap2) ... -
Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations
(Peer reviewed; Journal article, 2021)Ongoing neural activity has been observed across several brain regions and is thought to reflect the internal state of the brain. Yet, it is important to understand how ongoing neural activity interacts with sensory ... -
Heterogeneity of network and coding states in mouse CA1 place cells
(Journal article; Peer reviewed, 2023) -
Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents
(Peer reviewed; Journal article, 2023)The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing ... -
Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat
(Journal article; Peer reviewed, 2018)Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient ... -
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
(Peer reviewed; Journal article, 2020)The 5′ end of eukaryotic mRNAs is protected by the m7G-cap structure. The transcription start site nucleotide is ribose methylated (Nm) in many eukaryotes, whereas an adenosine at this position is further methylated at the ... -
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
(Peer reviewed; Journal article, 2016)Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of ... -
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
(Journal article; Peer reviewed, 2017)Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ... -
A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
(Peer reviewed; Journal article, 2021)Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve ... -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
(Peer reviewed; Journal article, 2020)Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ... -
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
(Peer reviewed; Journal article, 2023)The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that mediate escape from neutralizing antibodies. There is also evidence that mutations can cause loss of T cell epitopes. However, studies on ... -
PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery
(Journal article; Peer reviewed, 2016)Roux-en-Y gastric bypass (RYGB) is a weight-reduction procedure resulting in rapid resolution of type 2 diabetes (T2D). The role of pancreatic islet function in this restoration of normoglycemia has not been fully elucidated. ... -
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
(Peer reviewed; Journal article, 2021) -
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
(Peer reviewed; Journal article, 2022)Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in ...