Browsing Fakultet for medisin og helsevitenskap (MH) by Title

Now showing items 9283-9302 of 15139

    • Musikkterapiens effekt på agitasjon hos personer med demens 

      Nyborg, Marita (Bachelor thesis, 2023)
      Sammendrag Tittel: Musikkterapiens effekt på agitasjon hos personer med demens Introduksjon/bakgrunn: Personer med demens er en sårbar pasientgruppe i samfunnet vårt, og forekomsten av demens vil øke til det dobbelte om ...

    • Musikkterapiens effekt på livskvalitet hos personer med demens 

      Bårdstu, Erik Bauck (Bachelor thesis, 2022)
      Eldre personer med demens er en økende og sårbar gruppe i samfunnet. Pasientgruppen behøver bistand til å håndtere de utfordringene diagnosen medfører. Vernepleiere kan bidra med en systematisk og planlagt oppfølging, og ...

    • Mutasjonstesting ved ikke-småcellet lungekreft 

      Brustugun, Odd Terje; Helland, Åslaug; Fjellbirkeland, Lars; Kleinberg, Lilach; Ariansen, Sarah Louise; Jebsen, Peter Wilhelm; Scott, Helge; Dønnem, Tom; Bremnes, Roy M.; Berg, Thomas; Grønberg, Bjørn Henning; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Mangseth, Kjersti; Helgeland, Lars (Peer reviewed; Journal article, 2012)
      BAKGRUNN. Epidermal vekstfaktor-reseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer ...

    • Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

      Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Peer reviewed; Journal article, 2023)
      Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...

    • Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines 

      Giliberto, Mariaserena; Miranda Santana, Leonardo; Holien, Toril; Misund, Kristine; Nakken, Sigve; Vodak, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Coward, Eivind; Waage, Anders; Tasken, Kjetil; Skånland, Sigrid S (Peer reviewed; Journal article, 2022)
      Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ...

    • Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype 

      Grolleman, Judith E.; de Voer, Richarda M.; Elsayed, Fadwa A.; Nielsen, Maartje; Weren, Robbert D.A.; Palles, Claire; Ligtenberg, Marjolijn J.L.; Vos, Janet R.; ten Broeke, Sanne W.; de Miranda, Noel F.C.C.; Kuiper, Renske A.; Kamping, Eveline J.; Jansen, Erik A.M.; Vink-Börger, M. Elisa; Popp, Isabell; Lang, Alois; Spier, Isabel; Hüneburg, Robert; James, Paul A.; Li, Na; Staninova, Marija; Lindsay, Helen; Cockburn, David; Spasic-Boskovic, Olivera; Clendenning, Mark; Sweet, Kevin; Capellá, Gabriel; Sjursen, Wenche; Vetti, Hildegunn Høberg; Jongmans, Marjolijn C.; Neveling, Kornelia; van Kessel, Ad Geurts; Morreau, Hans; Hes, Frederik J.; Sijmons, Rolf H.; Schackert, Hans K.; Ruiz-Ponte, Clara; Dymerska, Dagmara; Lubiñski, Jan; Rivera, Barbara; Foulkes, William D.; Tomlinson, Ian P.; Valle, Laura; Buchanan, Daniel D.; Kenwrick, Sue; Adlard, Julian; Dimovski, Aleksandar J.; Campbell, Ian G.; Aretz, Stefan; Schindler, Detlev; van Wezel, Tom; Hoogerbrugge, Nicoline; Kuiper, Roland P. (Peer reviewed; Journal article, 2019)
      Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations ...

    • Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove 

      Rohrer, Karin; Haug, Markus; Schwoerer, Daniela; Kalbacher, Hubert; Holzer, Ursula (Journal article; Peer reviewed, 2014)
      Heat-shock protein 70 (Hsp70)–peptide complexes are involved in MHC class I- and II-restricted antigen presentation, enabling enhanced activation of T cells. As shown previously, mammalian cytosolic Hsp70 (Hsc70) molecules ...

    • MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP 

      Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S.A.; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Warpman Berglund, Ulrika; Stenmark, Pål; Helleday, Thomas (Journal article; Peer reviewed, 2018)
      Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ...

    • MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool 

      Scaletti, Emma Rose; Vallin, Karl S.A.; Bräutigam, Lars; Sarno, Antonio; Berglund, Ulrika Warpman; Helleday, Thomas; Stenmark, Pål; Jemth, Ann-Sofie (Peer reviewed; Journal article, 2020)
      MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ...

    • My Health Sensor, my Classifier – Adapting a Trained Classifier to Unlabeled End-User Data 

      Nikolaidis, Konstantinos; Kristiansen, Stein; Plagemann, Thomas Peter; Goebel, Vera Hermine; Liestøl, Knut; Kankanhalli, Mohan; Traaen, Gunn Marit; Øverland, Britt; Akre, Harriet; Aakerøy, Lars; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2022)
      Sleep apnea is a common yet severely under-diagnosed sleep related disorder. Unattended sleep monitoring at home with low-cost sensors can be leveraged for condition detection, and Machine Learning offers a generalized ...

    • My husband is not ill; He has memory loss - Caregivers perspectives on health care services for persons with dementia 

      Granbo, Randi; Boulton, Elisabeth; Saltvedt, Ingvild; Helbostad, Jorunn L.; Taraldsen, Kristin (Journal article; Peer reviewed, 2019)
      Background To explore informal caregivers’ perspectives and perceived needs related to health care services/activities for older adults with dementia, in order to understand barriers and facilitators to participation. The ...

    • MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy 

      Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)
      In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ...

    • MYC dysregulation in the progression of multiple myeloma 

      Misund, Kristine; Keane, Niamh; Stein, Caleb; Asmann, Yan; Day, GM; Welsh, Seth; Van Wier, Scott; Riggs, Daniel; Ahmann, Gregory; Chesi, Marta; Viswanatha, DS; Kumar, SK; Dispenzieri, Angela; Gonzalez-Calle, V; Kyle, RA; O'Dwyer, Michael; Rajkumar, SV; Kortüm, KM; Keats, JJ; Fonseca, R; Stewart, A.Keith; Kuehl, WM; Braggio, Esteban; Bergsagel, PL (Journal article; Peer reviewed, 2019)

    • Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition 

      Siegrist, M. Sloan; Steigedal, Magnus; Ahmad, Rushdy; Mehra, Alka; Dragset, Marte Singsås; Schuster, Brian M.; Phillips, Jennifer A.; Carr, Steven A.; Rubin, Eric J (Journal article; Peer reviewed, 2014)
      The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation ...

    • Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium 

      Kannan, Nisha; Haug, Markus; Steigedal, Magnus; Flo, Trude Helen (Peer reviewed; Journal article, 2020)
      Mycobacterium avium (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have ...

    • Mycoplasma genitalium and sexual behaviour: A cross-sectional study of students in Trondheim, Norway 

      Nitteberg, Silje Christine (Master thesis, 2016)
      Background: Screening of Mycoplasma genitalium is not recommended in Norway. Our objective was to investigate the prevalence of M. genitalium and associated sexual habits among students in Trondheim, Norway. Methods: In ...

    • Mycoplasma genitalium in the Far North Queensland backpacker population: An observational study of prevalence and azithromycin resistance 

      Trevis, Thomas; Gosse, Marianne; Santarossa, Nicola; Tabrizi, Sepehr; Russell, Darren; McBride, William John (Journal article; Peer reviewed, 2018)
      Background Mycoplasma genitalium is a sexually transmitted infection (STI), and a common cause of non-gonococcal urethritis (NGU). There is concern regarding the rise in prevalence of M. genitaliumand rates of resistance ...

    • Mycoplasma genitalium Macrolide-resistance and treatment options 

      Gossé, Marianne (Doctoral theses at NTNU;2020:360, Doctoral thesis, 2020)

    • Mycotic abdominal aortic aneurysm caused by Borrelia afzelii: a case report 

      Torsteinsen, Magne; Nilsen, Hans-Johnny; Damås, Jan Kristian; Stensvåg, Dordi; Nyrønning, Linn Ålstedt; Bergh, Kåre (Peer reviewed; Journal article, 2022)
      Background Inflammatory aneurysms and mycotic aneurysms make up a minority of abdominal aortic aneurysms. Mainly autoimmune mechanisms are proposed in the pathogenesis of inflammatory aneurysms, and it is not routine ...

    • Myeloma-derived extracellular vesicles mediate HGF/c-Met signaling in osteoblast-like cells 

      Strømme, Olaf; Psonka Antonczyk, Katarzyna Maria; Stokke, Bjørn Torger; Sundan, Anders; Arum, Carl-Jørgen; Brede, Gaute (Journal article; Peer reviewed, 2019)
      Multiple myeloma is an incurable cancer of antibody-producing plasma cells. Hepatocyte growth factor (HGF), a cytokine aberrantly expressed in half of myeloma patients, is involved in myeloma pathogenesis by enhancing ...