Browsing Fakultet for medisin og helsevitenskap (MH) by Title
Now showing items 3237-3256 of 15447
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DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
(Journal article; Peer reviewed, 2016)Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, ... -
DNA damage tolerance in human cells mediated by the APIM-containing proteins REV3L, HLTF, and SHPRH
(Doctoral theses at NTNU;2020:108, Doctoral thesis, 2020) -
DNA excision repair of uracil and 5-fluorouracil in human cancercell lines
(Doktoravhandlinger ved NTNU, 1503-8181; Doktoravhandlinger ved NTNU, 2009:260, Doctoral thesis, 2009)DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som. DNA kan ... -
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
(Peer reviewed; Journal article, 2020)The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ... -
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
(Peer reviewed; Journal article, 2021)Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ... -
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
(Journal article; Peer reviewed, 2020)Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional ... -
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
(Peer reviewed; Journal article, 2022)Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ... -
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis
(Journal article; Peer reviewed, 2019)Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide epigenetic patterns of DNA methylation ... -
DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome-including in elderly patients
(Peer reviewed; Journal article, 2022)Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences ... -
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
(Peer reviewed; Journal article, 2021)DNA repair enzymes are essential for the maintenance of the neuronal genome and thereby proper brain functions. Emerging evidence links DNA repair to epigenetic gene regulation; however, its contribution to different ... -
DNA Repair Enzyme NEIL3 Impacts Hippocampal Spatial Representations
(Master thesis, 2022)Endonuclease VIII-like 3 (NEIL3) DNA glycosylase er et enzym som spiller en rolle i initieringen av en viktig DNA reparasjonsprosess. I den siste tiden har det kommet frem nye funn som fremhever rollene NEIL3 spiller utenom ... -
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
(Peer reviewed; Journal article, 2022)Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ... -
DNA repair protein complexes, functionality and significance for repair efficiency and cell survival
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:146, Doctoral thesis, 2010)DNA‐reparasjons‐protein‐komplekser, funksjonalitet og signifikans for reparasjonseffektivitet og skadetoleranse All informasjon om en organisme er lagret i vår arvestoff, DNA. DNA er et relativt ustabilt makromolekyl som ... -
DNA topoisomerase IIα and mitosin expression predict meningioma recurrence better than histopathological grade and MIB-1 after initial surgery
(Journal article; Peer reviewed, 2017)Background: The 2016 WHO histopathological grade or conventional biomarker MIB-1 is insufficient for predicting meningioma recurrence after initial treatment and alternative strategies are required. In this study, we ... -
DNA-basert overvåking av den skandinaviske jervbestanden 2008-2011
(NINI rapport;843, Research report, 2012)Genetiske analyser er de siste årene blitt implementert som et viktig verktøy i rovviltovervåkingen i Skandinavia. I særlig grad har antallet DNA-analyser av ekskrementer økt betydelig. Det siste tiåret er det gjennomført ... -
Do abnormal serum lipid levels increase the risk of chronic low back pain? The Nord-Trøndelag Health Study
(Journal article; Peer reviewed, 2014)Background: Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP), but it is not known if there is any causal relationship. Objective: The objective was to ... -
Do Autistic Traits Predict Outcome of Cognitive Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder?
(Peer reviewed; Journal article, 2023)The first aim of this study was to explore whether children with obsessive compulsive disorder (OCD) and subclinical autistic traits can be differentiated from children with OCD without these traits based on clinical ... -
Do Brain Rhythms Change beforethe Migraine Attack?: A Longitudinal Controlled EEG Study
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:24, Doctoral thesis, 2011)Background The pathophysiological mechanisms that initiate a migraine attack at a particular time or in response to headache triggers are chiefly unknown. It is possible that a fluctuating change in cortical excitability ... -
Do Breast Cancer Patients Manage to Participate in an Outdoor, Tailored, Physical Activity Program during Adjuvant Breast Cancer Treatment, Independent of Health and Socio-Demographic Characteristics?
(Peer reviewed; Journal article, 2022)Exercise could reduce the side-effects of adjuvant breast cancer treatment; however, socio-demographic, health, and intervention conditions may affect patients’ adherence to interventions. This study aimed to examine ... -
Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?
(Peer reviewed; Journal article, 2022)Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?